Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The role of T regulatory lymphocytes in lymphoma

Tue Jul 23 08:52:40 2024

(2014) The role of T regulatory lymphocytes in lymphoma. Middle East Journal of Cancer. pp. 55-66. ISSN 20086709 (ISSN)

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T regulatory cells play a crucial role in immunological unresponsiveness to selfantigens and in suppressing excessive immune responses deleterious to the host. T regulatory cells are produced in the thymus as a functionally mature subpopulation of T cells. They can be induced from naive T cells in the periphery and express their marker as a forkhead/winged helix transcription factor called FoxP3. In patients with lymphomas where T regulatory cells serve as suppressor anti-tumor cytotoxicity, decreased numbers of T regulatory cells are associated with a favorable prognosis. In contrast, in patients with lymphomas where T regulatory cells function as anti-tumor cytotoxic agents, enhanced numbers of T regulatory cells are associated with a favorable prognosis. Tumors actively promote the accumulation of these cells through several mechanisms that involve activation of naturally occurring T regulatory cells as well as conversion of non-T regulatory cells into T regulatory cells. Tumor-derived prostaglandin E2 can increase T regulatory cell activity and induce a regulatory phenotype in CD4+CD25+T cells. On the other hand, a balance between T regulatory and Th17 cells is essential for maintaining homeostasis of anti-tumor immunity. Accelerating processes such as increasing the amounts of IL-6 or IL-17 can enhance FoxP3 T regulatory cell expression and result in a lymphoma or inactivation of T cell CD4+. This effect is the reason for malignancy and a reduction in anti-tumor immune response. In this systematic review we intend to analyze this relationship. We have collected and analyzed the majority of recently published articles on the role of T regulatory cells as a review article.

Item Type: Article
Keywords: FoxP3 Lymphoma Malignancy Treg alemtuzumab antigen B cell activating factor CD28 antigen CD39 antigen CD45RA antigen CD45RO antigen chemokine receptor CCR cyclophosphamide cytotoxic T lymphocyte antigen 4 Fas antigen fludarabine gamma interferon glucocorticoid induced tumor necrosis factor receptor inducible T cell costimulator ligand interleukin 10 interleukin 2 interleukin 2 receptor alpha interleukin 2 receptor beta interleukin 2 receptor gamma interleukin 6 interleukin 7 interleukin 7 receptor L selectin prostaglandin E2 T lymphocyte receptor transcription factor FOXP3 transcription factor NFAT transforming growth factor beta unindexed drug autoimmune disease Burkitt lymphoma CD4+ CD25+ T lymphocyte CD8+ T lymphocyte cell migration Epstein Barr virus Hodgkin disease homeostasis human immune response Langerhans cell lymphocytoma marginal zone lymphoma mycosis fungoides nonhodgkin lymphoma nonhuman phenotype Reed Sternberg cell regulatory T lymphocyte review Sezary syndrome steady state systematic review Th17 cell thymus tumor associated leukocyte tumor growth Waldenstroem macroglobulinemia
Page Range: pp. 55-66
Journal or Publication Title: Middle East Journal of Cancer
Journal Index: Scopus
Volume: 5
Number: 2
ISSN: 20086709 (ISSN)
Depositing User: مهندس مهدی شریفی

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