Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Association of kcnj11 E23K promoter polymorphism with type 2 diabetes

Sat Jun 25 09:12:29 2022

(2015) Association of kcnj11 E23K promoter polymorphism with type 2 diabetes. Journal of Mazandaran University of Medical Sciences. pp. 1-8. ISSN 17359279 (ISSN)

Full text not available from this repository.

Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Background and purpose: The E23K polymorphism of ATP-sensitive potassium channel kcnj11 gene leads to the conversion of glutamate to lysine amino acids and this substitution is associated with increased risk of several diseases such as diabetes. We aimed to examine the association between kcnj11 E23K variation and risk of type 2 diabetes mellitus (T2DM) in a Kurdish population. Material and methods: The study population included 173 patients with T2DM and 173 normoglycemic subjects. All subjects were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Genotypic and allelic frequencies were then analyzed in each group. Serum lipids, fasting glucose, fasting serum insulin, HOMA-IR, and HbA1c levels were also determined. Data analysis was performed using SPSS software. Results: Significant differences were seen between the two groups for allelic frequency of the T allele (P=0.006). Also, the genotype frequencies showed a significant difference in CT genotype between the case and control individuals (OR=2.77, 95 CI: 1.29-5.97, P=0.009). Similarly, in the dominant model, the kcnj11 E23K was found to be significantly associated with T2DM (OR=2.72, 95 CI: 1.30- 5.68, P=0.008). However, we did not observe any significant association in the recessive model (P>0.05). Conclusion: This study was performed for the first time in the Kurdish ethnic group in Iran. The E23K polymorphism of the kcnj11 was found to be significantly associated with T2DM in the studied population. © 2015 Mazandaran University of Medical Sciences. All rights reserved.

Item Type: Article
Creators:
CreatorsEmail
Sayehmiri, F.UNSPECIFIED
Moshtaghie, A. A.UNSPECIFIED
Bakhtiyari, S.UNSPECIFIED
Keywords: E23K Kcnj11 Kurd Type 2 diabetes glutamic acid inwardly rectifying potassium channel subunit Kir6.2 lysine amino acid substitution Article disease association gene frequency genetic polymorphism genetic variability genotype glucose blood level human insulin blood level Kurd (people) lipid blood level major clinical study non insulin dependent diabetes mellitus polymerase chain reaction promoter region restriction fragment length polymorphism
Divisions:
Page Range: pp. 1-8
Journal or Publication Title: Journal of Mazandaran University of Medical Sciences
Journal Index: Scopus
Volume: 25
Number: 121
ISSN: 17359279 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1474

Actions (login required)

View Item View Item