Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Association of TNF-α 308G/A polymorphism with type 2 diabetes: A case-control study in the Iranian Kurdish ethnic group

Mon Jun 17 02:16:08 2024

(2015) Association of TNF-α 308G/A polymorphism with type 2 diabetes: A case-control study in the Iranian Kurdish ethnic group. Osong public health and research perspectives. pp. 94-99. ISSN 22109099 (ISSN)

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Objectives: Tumor necrosis factor-α (TNF-α) plays roles in the development of obesity, insulin resistance, and possibility of Type 2 diabetes mellitus (T2DM). The objective of the current study was to evaluate the association of TNF-α promoter-308G/A polymorphism with T2DM. Methods: In all, 1038 patients with T2DM and 1023 normoglycemic controls were included in this study. All participants were genotyped using the polymerase chain reaction-restriction fragment length polymorphism method. Genotypic and allelic frequencies were then analyzed in each group. Serum lipids, fasting glucose, fasting serum insulin, homeostatic model assessment of insulin resistance, and hemoglogin A1c levels were determined by conventional methods. Results: The allelic frequency of the A allele was significantly different between case and control participants (p = 0.006). Genotypes GA and AA were found to be significantly associated with 2.24- and 3.18-fold increased risk for T2DM, respectively. Similarly, the dominant model of -308G/A polymorphism was found to have a higher risk for T2DM (odds ratio = 2.34, p = 0.001). Individuals with T2DM carrying the GA+AA genotypes of -308G/A variation had significantly lower fasting plasma insulin than those carrying GG genotype. Conclusion: Our findings revealed that there is an association between the TNF-α promoter -308G/A polymorphism and T2DM in this population. © 2015 Korea Centers for Disease Control and Prevention.

Item Type: Article
Keywords: -308 TNF-α promoter Case-control Kurd Polymorphism Type 2 diabetes cholesterol glucose hemoglobin A1c high density lipoprotein cholesterol insulin low density lipoprotein cholesterol triacylglycerol tumor necrosis factor alpha adult Article cholesterol blood level controlled study female gene frequency genetic association genetic polymorphism genetic risk genetic variability genotype glucose blood level hemoglobin blood level human insulin blood level insulin resistance Kurd (people) lipid blood level major clinical study male non insulin dependent diabetes mellitus polymerase chain reaction priority journal promoter region restriction fragment length polymorphism triacylglycerol blood level
Page Range: pp. 94-99
Journal or Publication Title: Osong public health and research perspectives
Journal Index: Scopus
Volume: 6
Number: 2
Identification Number:
ISSN: 22109099 (ISSN)
Depositing User: مهندس مهدی شریفی

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