Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Comparison of quinolone and β-lactam resistance among Escherichia coli strains isolated from urinary tract infections

Mon Jul 22 14:14:08 2024

(2016) Comparison of quinolone and β-lactam resistance among Escherichia coli strains isolated from urinary tract infections. Infezioni in Medicina. pp. 326-330. ISSN 11249390 (ISSN)

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The growing frequency of antibiotic resistances is now a universal problem. Increasing resistance to new generations of β-lactam and quinolone antibiotics in multidrug- resistant Enterobacteriaceae isolates is considered an emergency health issue worldwide. The aim of this study was to evaluate plasmid-mediated quinolone resistance genes in ESBL-producing Escherichia coli isolated from urinary tract infections (UTIs). In our study ESBL- producing isolates were assessed by screening methods. After determination of antimicrobial susceptibility, detection of ESBLs and quinolone resistance genes was performed. A total of 97 ESBL-producing E. coli were determined. The blaTEM, blaSHV and blaCTX-M genes were detected in 90 isolates. The blaTEM was the most frequent- ly detected gene (46.4), followed by blaSHV (31.9) and blaCTX-M (14.4). The most prevalent quinolone resistance gene among ESBL-producing isolates was oqxAB which found in 67 isolates (69.1). The frequencies of the aac(6’)-Ib-cr, qnr and qepA were 65 (67), 8 (8.2) and 6 (6.2), respectively. Our data indicate that the prevalence of plasmid-mediated quinolone resistance genes in ESBL-positive isolates is increasing. The co-dissemination of PMQR and ESBL genes among E. coli isolates can be considered a threat to public health. Therefore, prescription of antibiotics against infectious disease should be managed carefully. © 2016, International Society of Musculoskeletal and Neuronal Interactions. All rights reserved.

Item Type: Article
Keywords: E. coli ESBL Iran Quinolone UTI amikacin beta lactam antibiotic cefotaxime ceftazidime ceftriaxone chloramphenicol ciprofloxacin cotrimoxazole doxycycline gentamicin meropenem nitrofurantoin piperacillin plus tazobactam quinoline derived antiinfective agent tobramycin antiinfective agent beta lactam beta lactamase quinolone derivative aac(6′) Ib cr antibiotic resistance Article bacterial gene bacterial strain bacterium detection bacterium isolation bla ctx m gene bla shv gene bla tem gene DNA extraction extended spectrum beta lactamase producing Escherichia coli gene frequency human major clinical study nonhuman oqxab gene plasmid qepa gene qnr gene screening urinary tract infection comparative study complication cross-sectional study Escherichia coli Escherichia coli infection genetics genotype hospital hospital patient isolation and purification microbial sensitivity test microbiology multidrug resistance outpatient prevalence statistics and numerical data Anti-Bacterial Agents beta-Lactam Resistance beta-Lactamases beta-Lactams Cross-Sectional Studies Drug Resistance, Multiple, Bacterial Escherichia coli Infections Hospitals Humans Inpatients Microbial Sensitivity Tests Outpatients Quinolones Urinary Tract Infections
Page Range: pp. 326-330
Journal or Publication Title: Infezioni in Medicina
Journal Index: Scopus
Volume: 24
Number: 4
ISSN: 11249390 (ISSN)
Depositing User: مهندس مهدی شریفی

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