Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Signaling pathways of melatonin in prevention of liver disorders via suppressing of oxidative stress in cellular level

(2016) Signaling pathways of melatonin in prevention of liver disorders via suppressing of oxidative stress in cellular level. Biomedical and Pharmacology Journal. pp. 555-561. ISSN 09746242 (ISSN)

Full text not available from this repository.

Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Melatonin (MT) (N-acetyl-5-methoxytryptamine) is a lipophilic and hydrophilic indoleamine with various physiologic functions MT presents in all cells and tissues and distributes in all cell compartments. Liver is the only organ of circulating MT metabolism. The roles of MT in various liver pathologies have been extensively studied, and it is believed that oxidative stress (OS) and lipid peroxidation (LPO) are the key causing factors of almost all conditions compromising liver function, including nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), diabetes, liver fibrosis and cirrhosis. MT improves energy production and reduces apoptosis OS and LPO in liver. MT protects liver against OS through multiple ways: inhibition of inflammatory cytokines, direct scavenge of free radicals, stimulation of antioxidant enzymes, decrease of mitochondrial electron leakage and synergistic function with other classical antioxidants. © 2016, Oriental Scientific Publishing Company. All rights reserved.

Item Type: Article
Keywords: Free radical Liver disease Melatonin Reactive oxygen species antioxidant cytokine indoleamine apoptosis Article diabetes mellitus drug metabolism energy yield human lipid peroxidation lipophilicity liver cirrhosis liver fibrosis mitochondrion nonalcoholic fatty liver oxidative stress
Divisions:
Page Range: pp. 555-561
Journal or Publication Title: Biomedical and Pharmacology Journal
Journal Index: Scopus
Volume: 9
Number: 2
Identification Number: https://doi.org/10.13005/bpj/972
ISSN: 09746242 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1427

Actions (login required)

View Item View Item