Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Mutation and Efflux System are Responsible for Ciprofloxacin Resistance in Klebsiella pneumoniae

Wed Sep 28 12:09:09 2022

(2018) Mutation and Efflux System are Responsible for Ciprofloxacin Resistance in Klebsiella pneumoniae. West Indian Medical Journal. pp. 226-228. ISSN 0043-3144

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Abstract

The main mechanism of quinolone resistance in Klebsiella (K) pneumoniae is caused by mutation ofporin-related proteins and efflux pumps. This study aimed to investigate the prevalence of ciprofloxacin-resistant K pneumoniae in burns patients and to understand the role of the AcrAB multidrug efflux system on minimal inhibitory concentration (MIC) of ciprofloxacin. For this reason, 52 K pneumoniae samples were collected from burns patients and evaluated for the mechanism of ciprofloxacin resistance. The results demonstrated that 40 isolates of K pneumoniae were ciprofloxacin-resistant and 35 showed the mutation on gyrA locus. By inhibition of the efflux system, the MIC yield showed a significant decrease. Therefore, it could be concluded that the high rate of mutation on the gyrA locus in combination with quinolone resistance was responsible for ciprofloxacin resistance and by inhibition of AcrA, the resistance rate showed a significant decrease in K pneumoniae isolated from burns patients.

Item Type: Article
Creators:
CreatorsEmail
Zayyen, K. M.UNSPECIFIED
Rastegar-Lari, A.UNSPECIFIED
Ghafourian, S.UNSPECIFIED
Taherikalani, M.UNSPECIFIED
Sadeghifard, N.UNSPECIFIED
Jalilian, F. A.UNSPECIFIED
Badakhsh, B.UNSPECIFIED
Hematian, A.UNSPECIFIED
Pakzad, I.UNSPECIFIED
Keywords: Ciprofloxacin efflux Klebsiella pneumoniae mutation General & Internal Medicine
Divisions:
Page Range: pp. 226-228
Journal or Publication Title: West Indian Medical Journal
Journal Index: ISI
Volume: 67
Number: 3
Identification Number: https://doi.org/10.7727/wimj.2015.324
ISSN: 0043-3144
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/138

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