Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Application of nanomedicine for crossing the blood–brain barrier: Theranostic opportunities in multiple sclerosis

Tue Oct 4 00:21:37 2022

(2016) Application of nanomedicine for crossing the blood–brain barrier: Theranostic opportunities in multiple sclerosis. Journal of Immunotoxicology. pp. 603-619. ISSN 1547691X (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Multiple sclerosis (MS) is an autoimmune neurodegenerative disease characterized with immunopathobiological events, including lymphocytic infiltration into the central nervous system (CNS), microglia activation, demyelination and axonal degeneration. Although several neuroprotective drugs have been designed for the treatment of MS, complete remission is yet matter of debate. Therefore, development of novel therapeutic approaches for MS is of a high priority in immunological research. Nanomedicine is a recently developed novel medical field, which is applicable in both diagnosis and treatment of several cancers and autoimmune diseases. Although there is a marked progress in neuroimaging through using nanoparticles, little is known regarding the therapeutic potential of nanomedicine in neurological disorders, particularly MS. Moreover, the majority of data is limited to the MS related animal models. In this review, we will discuss about the brain targeting potential of different nanoparticles as well as the role of nanomedicine in the diagnosis and treatment of MS and its animal model, experimental autoimmune encephalomyelitis. © 2016 Informa UK Limited trading as Taylor & Francis Group.

Item Type: Article
Creators:
CreatorsEmail
Ghalamfarsa, G.UNSPECIFIED
Hojjat-Farsangi, M.UNSPECIFIED
Mohammadnia-Afrouzi, M.UNSPECIFIED
Anvari, E.UNSPECIFIED
Farhadi, S.UNSPECIFIED
Yousefi, M.UNSPECIFIED
Jadidi-Niaragh, F.UNSPECIFIED
Keywords: Blood–brain barrier Diagnosis Experimental autoimmune encephalomyelitis Nanoparticle Neuroinflammation carbon nanoparticle dendrimer liposome nanocapsule nanosphere solid lipid nanoparticle neuroprotective agent blood brain barrier central nervous system drug delivery system gel micelle multiple sclerosis nanoemulsion nonhuman polymerization priority journal Review theranostic nanomedicine animal diagnostic imaging disease model drug effects Encephalomyelitis, Autoimmune, Experimental human mouse neurogenic inflammation utilization Animals Blood-Brain Barrier Disease Models, Animal Humans Mice Nanoparticles Neuroprotective Agents
Divisions:
Page Range: pp. 603-619
Journal or Publication Title: Journal of Immunotoxicology
Journal Index: Scopus
Volume: 13
Number: 5
Identification Number: https://doi.org/10.3109/1547691X.2016.1159264
ISSN: 1547691X (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1354

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