Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Risk factors of nonalcoholic fatty liver disease: A case-control study

Wed Jun 19 07:17:44 2024

(2016) Risk factors of nonalcoholic fatty liver disease: A case-control study. Tehran University Medical Journal. pp. 645-656. ISSN 16831764 (ISSN)

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Background: Considering the high incidence and prevalence of nonalcoholic fatty liver disease (NAFLD) in the Iranian society and the limited number of studies to investigate its associated risk factors, the current study was designed to identify any relevant risk factor of this disease. Methods: The present case-control study was performed among 150 nonalcoholic fatty liver disease patients and 150 normal liver participants who attended to gastroenterology clinics in Ilam city, Iran during 2014-2015. All demographic data, clinical trials and health behaviors associated with lifestyle such as nutritional status, smoking, physical activities were collected and compared between two groups. Results: Among a total of 300 participants in the current study, the male female ratio was 46.54 and the mean±standard deviation of all participants was 42.13±12.15 years. The mean values of total cholesterol, triglycerides (TG), low density lipoprotein (LDL), alanine transaminase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were significantly higher in cases than controls group (P< 0.0001). A significant relationship was revealed between positive familial history, marriage, and low physical activities with NAFLD (P< 0.05). In the patient's group, consumption of red meat was significantly higher and dairy intake was significantly lower compared to the control group (P< 0.05). Using the multivariate logistic regression analysis, the adjusted odds ratio for variables of waist circumference, triglyceride, ALT and body mass index (BMI) were statistically significant 1.11, (1.04-1.18); 2.58, (1.01-6.67); 5.34, (1.84-15.52) and 7.28, (1.89-27.99) respectively (P< 0.05). Also, a significant association was observed among the variables of ALT, AST and BMI with the severity grade of NAFLD (P< 0.05). Conclusion: The results of this study showed that waist circumference, BMI, serum level of ALT and TG concentrations can predict the occurrence of non-alcoholic fatty liver disease. BMI, ALT, and AST seem to be associated with the ultrasonography staging of liver in NAFLD. Therefore, these parameters could be used to predict the ultrasonography staging of liver in these patients. © 2016, Tehran University of Medical Sciences. All rights reserved.

Item Type: Article
Keywords: Alanine transaminase Body mass index Case-control studies Non-alcoholic fatty liver disease Risk factors alanine aminotransferase alkaline phosphatase aspartate aminotransferase cholesterol low density lipoprotein triacylglycerol adult Article body mass case control study controlled study dairy product female food intake human major clinical study male nonalcoholic fatty liver red meat risk factor waist circumference
Page Range: pp. 645-656
Journal or Publication Title: Tehran University Medical Journal
Journal Index: Scopus
Volume: 74
Number: 9
ISSN: 16831764 (ISSN)
Depositing User: مهندس مهدی شریفی

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