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Repository of Research and Investigative Information

Ilam University of Medical Sciences

Curcumin in combination with triple therapy regimes ameliorates oxidative stress and histopathologic changes in chronic gastritis– associated helicobacter pylori infection

Thu Aug 18 17:52:19 2022

(2017) Curcumin in combination with triple therapy regimes ameliorates oxidative stress and histopathologic changes in chronic gastritis– associated helicobacter pylori infection. Arquivos de gastroenterologia. pp. 177-182. ISSN 00042803 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Background – Helicobacter pylori (H. pylori) gastric infection is a main cause of inflammatory changes and gastric cancers. Objective – The aim of this study was finding the effects of curcumin on oxidative stress and histological changes in chronic gastritis associated with H. pylori. Methods – In a randomized clinical trial, patients were divided into two groups: a standard triple therapy group and triple therapy with curcumin group. Endoscopic and histological examinations were measured for all patients before and after 8 weeks. Results – Triple therapy with curcumin treatment group significantly decreased malondialdehyde markers, glutathione peroxides and increased total antioxidant capacity of the gastric mucosa at the end of study compared to baseline and triple regimen groups. In addition, the oxidative damage to DNA was significantly decreased in triple therapy with curcumin group at the end of study compared to baseline and compared to triple therapy (P<0.05 for both). Triple therapy group in combination with Curcumin significantly decreased all active, chronic and endoscopic inflammation scores of patients compared to the baseline and triple therapy group (P<0.05 for both). The eradication rate by triple therapy + curcumin was significantly increased compared to triple therapy alone (P<0.05). Conclusion – Curcumin can be a useful supplement to improve chronic inflammation and prevention of carcinogenic changes in patients with chronic gastritis associated by H. pylori. © 2017, IBEPEGE - Inst. Bras. Estudos Pesquisas Gastroent. All rights reserved.

Item Type: Article
Creators:
CreatorsEmail
Judaki, A.UNSPECIFIED
Rahmani, A.UNSPECIFIED
Feizi, J.UNSPECIFIED
Asadollahi, K.UNSPECIFIED
Hafezi Ahmadi, M. R.UNSPECIFIED
Keywords: Curcumin DNA damage Gastritis Helicobacter pylori Oxidative stress amoxicillin glutathione peroxidase malonaldehyde metronidazole nonsteroid antiinflammatory agent omeprazole adult antiinflammatory activity antioxidant activity antioxidant assay Article chronic gastritis chronic inflammation clinical assessment controlled study female gastrointestinal endoscopy Helicobacter infection histopathology human human tissue lipid peroxidation major clinical study male pathogen clearance randomized controlled trial rapid urease test stomach antrum stomach biopsy stomach mucosa adolescent aged chronic disease combination drug therapy complication drug effects Helicobacter Infections microbiology middle aged pathology treatment outcome young adult Anti-Inflammatory Agents, Non-Steroidal Drug Therapy, Combination Humans
Divisions:
Page Range: pp. 177-182
Journal or Publication Title: Arquivos de gastroenterologia
Journal Index: Scopus
Volume: 54
Number: 3
Identification Number: https://doi.org/10.1590/s0004-2803.201700000-18
ISSN: 00042803 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1289

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