Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Tumor necrosis factor-alpha 308 G/A polymorphism and type 2 diabetes mellitus; a systematic review and meta-analysis

Thu Oct 6 07:07:50 2022

(2018) Tumor necrosis factor-alpha 308 G/A polymorphism and type 2 diabetes mellitus; a systematic review and meta-analysis. Journal of nephropathology. pp. 25-31. ISSN 22518363 (ISSN)

Full text not available from this repository.

Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Context: Type 2 diabetes mellitus (T2DM) is a multi-factorial disease with several genetic and environmental factors known to be associated with the disease. Tumor necrosis factor-alpha (TNF-α) acts on fat cells associated with increased insulin resistance and obesity and its increase can be associated with the prevalence of T2DM. Previous studies on the relationship between 308 G/A polymorphism in TNF-α and T2DM were not conclusive. The aim of this study was to investigate the association between 308 G/A polymorphism in TNF-α gene and T2DM using a systematic review and meta-analysis. Evidence Acquisitions: In this systematic review we searched all published studies about the association between TNF 308 G/A polymorphism and T2DM through databases such as Scopus, Science direct, PubMed and Google scholar. A fixed or random effect model was used on the basis of heterogeneity. The heterogeneity was assessed using the I2 index. We used STATA software (version 11.2) for data analysis. Results: In 22 selected papers, the total number of T2DM and control subject was 8485 and 8615, respectively. Odds ratios (ORs) with 95 confidence intervals(CI) for the GG genotype polymorphism 308 G/A in total, Asian populations and whites (Caucasian) were estimated as OR = 0.98 (95 CI: 0.96-1.00), OR = 0.96 (95 CI: 0.93 to 0.99) and OR =1.00 (95 CI: 0.97 to 1.40). The Publication Bias/or heterogeneity was observed in this study. Conclusions: The present investigation have shown that 308 G/A polymorphism GG and GA genotypes in TNF-α gene cannot be considered as predictors of T2DM (P < 0.05). © 2018 The Author(s).

Item Type: Article
Creators:
CreatorsEmail
Dehkordi, A. H.UNSPECIFIED
Dousti, M.UNSPECIFIED
Kiani, F.UNSPECIFIED
Azodi, M. Z.UNSPECIFIED
Rezaei-Tavirani, M.UNSPECIFIED
Sayehmiri, K.UNSPECIFIED
Keywords: 308 G/A Diabetes mellitus type 2 Polymorphism TNF-α tumor necrosis factor adipocyte Asian bibliographic database clinical decision making diabetic patient genetic association human insulin resistance meta analysis non insulin dependent diabetes mellitus obesity population prevalence Review risk factor single nucleotide polymorphism systematic review
Divisions:
Page Range: pp. 25-31
Journal or Publication Title: Journal of nephropathology
Journal Index: Scopus
Volume: 7
Number: 1
Identification Number: https://doi.org/10.15171/jnp.2018.09
ISSN: 22518363 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1258

Actions (login required)

View Item View Item