Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Renal blood flow and vascular resistance responses to angiotensin II in irreversible and reversible unilateral ureteral obstruction rats; the role of angiotensin II type 1 and 2 receptors

Fri Dec 9 22:20:58 2022

(2018) Renal blood flow and vascular resistance responses to angiotensin II in irreversible and reversible unilateral ureteral obstruction rats; the role of angiotensin II type 1 and 2 receptors. Journal of nephropathology. pp. 57-64. ISSN 22518363 (ISSN)

Full text not available from this repository.

Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Background: Unilateral ureteral obstruction (UUO) alters the expression of renin-angiotensin system (RAS) components and angiotensin II (Ang II) as the main arm of RAS is affected by UUO. Objectives: In this study the role of Ang II subtypes 1 and 2 receptors (AT1R and AT2R) antagonists (losartan and PD123319) was examined in renal hemodynamic responses to graded Ang II infusion in sham, 3-day UUO and removal UUO (RUUO) models in rats. Materials and Methods: Seventy-one male Wistar rats randomly divided into three different sets of animal models; sham-operated, UUO and RUUO that each set contains three groups treated with vehicle, losartan, and PD123319. Renal vascular responses to Ang II infusion were measured at controlled renal perfusion pressure (RPP). Results: The graded Ang II infusion decreased renal blood flow (RBF), increased renal vascular resistance (RVR) and mean arterial pressure (MAP) in vehicle or PD123319 treated groups significantly (P < 0.005), but no significant difference was found between these treated groups. However, RBF, RVR and MAP responses to graded Ang II infusion in losartan-treated rats were attenuated significantly when compared with vehicle or PD123319 treated groups (P < 0.05). In addition, the RBF, RVR and MAP responses to Ang II were not similar in sham, UUO and RUUO rats treated with losartan. Conclusions: Vascular responses to Ang II in UUO and RUUO rat model treated with losartan is not as the normal pattern. © 2018 The Author(s).

Item Type: Article
Creators:
CreatorsEmail
Hassanshahi, J.UNSPECIFIED
Maleki, M.UNSPECIFIED
Nematbakhsh, M.UNSPECIFIED
Keywords: Angiotensin II Losartan PD123319 Renal blood flow Renal vascular resistance Unilateral ureteral obstruction 1 (4 dimethylamino 3 methylbenzyl) 5 diphenylacetyl 4,5,6,7 tetrahydro 1h imidazo4,5 cpyridine 6 carboxylic acid angiotensin 1 receptor angiotensin 2 receptor animal experiment animal model Article controlled study hemodynamics kidney blood flow kidney perfusion male mean arterial pressure nonhuman perfusion pressure rat treatment response ureter obstruction vascular resistance
Divisions:
Page Range: pp. 57-64
Journal or Publication Title: Journal of nephropathology
Journal Index: Scopus
Volume: 7
Number: 2
Identification Number: https://doi.org/10.15171/jnp.2018.15
ISSN: 22518363 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1256

Actions (login required)

View Item View Item