Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Effect of estradiol and soy extract administration on pentylenetetrazole induced clonic seizures and serum levels of nitric oxide metabolites in ovariectomized rats

Thu Aug 11 15:42:29 2022

(2018) Effect of estradiol and soy extract administration on pentylenetetrazole induced clonic seizures and serum levels of nitric oxide metabolites in ovariectomized rats. Koomesh. pp. 569-574. ISSN 16087046 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Introduction: Estrogen influences neuronal activity and there are controversial reports regarding its role on seizure. Also, previous studies have shown that estrogen influences the nitric oxide pathway in the nervous system. In this way, the aim of the present study was to investigate the effect of estradiol and soy extract as a phytoestrogen on pentylenetetrazole-induced clonic seizures and serum levels of nitric oxide metabolites (NOx) in ovariectomized rats. Materials and Methods: Sixty female Wistar rats were randomly divided into six groups (n =10 in each group) including intact control, sham-control, ovariectomy, vehicle, estradiol (100 μg/kg, subcutaneously), and soy extract (20 mg/kg, gavage). After 28 days of estradiol or soy extract adminstration, single dose of pentylenetetrazole was injected (90 mg/kg, intraperitoneally) for seizure induction and latency to the clonic seizures was recorded. Serum levels of NOx were measured by Griess method. Results: Ovariectomy significantly reduced the latency of clonic seizures and serum levels of NOx. Estradiol significantly increased the latency of clonic seizures and serum levels of NOx (P < 0.05). Soy administration had not significant effect on these parameters. Conclusion: Ovarian hormones have influence on seizure and nitric oxide pathway anticonvulsant effect of estradiol is related due to modulation of nitric oxide pathway slightly. © 2018, Semnan University of Medical Sciences. All rights reserved.

Item Type: Article
Creators:
CreatorsEmail
Heydari, A.UNSPECIFIED
Hamidi, H.UNSPECIFIED
Salami, M.UNSPECIFIED
Arbabi, E.UNSPECIFIED
Alavi, S. S.UNSPECIFIED
Hadizadeh, M.UNSPECIFIED
Afsordeh, N.UNSPECIFIED
Keywords: Estradiol Nitric oxide Ovariectomy Pentylenetetrazole Seizure Soybean pentetrazole phytoestrogen soybean extract animal experiment animal model animal tissue anticonvulsant activity Article clonic seizure controlled study female nonhuman rat
Divisions:
Page Range: pp. 569-574
Journal or Publication Title: Koomesh
Journal Index: Scopus
Volume: 20
Number: 3
ISSN: 16087046 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1245

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