Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Study of SOX2, OCT4 and NANOG Genes Expression in Peripheral Blood of Patients with Non-small Cell Lung Cancer (NSCLC)

Wed Jul 24 10:37:45 2024

(2018) Study of SOX2, OCT4 and NANOG Genes Expression in Peripheral Blood of Patients with Non-small Cell Lung Cancer (NSCLC). Journal of Research in Medical and Dental Science. pp. 295-300. ISSN 2347-2545

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Abstract

Introduction: lung cancer is a disease that is characterized by an uncontrolled growth of the cell in the lung tissue. This cancer is the most common cause of cancer death worldwide. The SOX2, OCT4 and NANOG transcription factor are the main regulators of maintaining vitality state and self-renewal in embryonic stem cells. The aim of this study was to evaluate the genes expression of SOX2 in peripheral blood of patients with non-small cell lung cancer (NSCLC). Material and Methods: in this research, the expression of SOX2, OCT4 and NANOG transcription factors were investigated in peripheral blood of 30 patients with NSCLC. For this purpose, after RNA extraction from patients' blood by TRIzol then cDNA synthesis, the expression of the genes was analyzed by Real Time PCR technique and using specific primers for the genes. Results: after reviewing the results by Graph Pad software and t-test, SOX2, OCT4 and NANOG expression in patient samples was significantly higher than normal samples. Discussion: the expression of the genes studied in this research in the patients with lung cancer was significantly higher than normal. Regarding the gene expression profile, it seems that the gene is a potential biomarker for the diagnosis of lung cancer.

Item Type: Article
Creators:
CreatorsEmail
Mojtahedifard, N.UNSPECIFIED
Larki, P.UNSPECIFIED
Panahi, J.UNSPECIFIED
Moghadam, M. H.UNSPECIFIED
Karizi, S. Z.UNSPECIFIED
Keywords: NANOG OCT4 SOX2 NSCLC Non-small Cell Lung Cancer embryonic stem-cells self-renewal pluripotency identification adenocarcinoma carcinoma Research & Experimental Medicine
Divisions:
Page Range: pp. 295-300
Journal or Publication Title: Journal of Research in Medical and Dental Science
Journal Index: ISI
Volume: 6
Number: 1
Identification Number: https://doi.org/10.24896/jrmds.20186148
ISSN: 2347-2545
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/124

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