Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Reactive oxygenated species (ROS) in male fertility; source, interaction mechanism and antioxidant therapy

Tue Oct 4 03:15:57 2022

(2018) Reactive oxygenated species (ROS) in male fertility; source, interaction mechanism and antioxidant therapy. Research Journal of Pharmacy and Technology. pp. 791-796. ISSN 09743618 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Currently ROS is known as the cause of many diseases and damage to cells and tissues. Many studies have shown that ROS is related to diseases such as cancer, cardiovascular, diabetic nephropathy and even processes such as aging and infertility. The studies of the past two decades reveal that low and controlled ROS values in the physiological process of the cell are secondary; while their physiological values is essential for the normal activity of the cell. Studies show that in most cells, the physiological amounts of ROS are produced by NADPH oxidase family enzymes. These enzymes are present in the plasma membrane of the cells, where they increase the production of ROS by connecting them with calcium. ROS in sperm also plays different physiological roles from the time of its production to the time of its emergence with an oocyte, but the pathological effects of its excessive production are also evident. This includes increasing the damage to DNA and increasing sperm apoptosis, which is responsible for including infertility in an important part of interfile men. In the infertility treatment clinics, that their number of clients is increasing every day, sperms find fertilization opportunity with the oocyte in the culture medium; but prior to that, sperm should passes different washing steps. These washing processes increase ROS production. The production of ROS is increased by the method of separating the sperm by centrifuging and then allowing sperm moves to float. This is one of the common methods in infertility treatment centers for sperm washing, while the sperm in washing stages has been deprived of its antioxidant source. Therefore, the use of vitamins either orally or in a sperm medium can increase the chances of fertilization and fertility of infertile individuals by preventing the motility of sperm and preventing their increased mortality and reducing DNA damage. © RJPT All right reserved.

Item Type: Article
Creators:
CreatorsEmail
Fatehi, D.UNSPECIFIED
Moayeri, A.UNSPECIFIED
Rostamzadeh, O.UNSPECIFIED
Rostamzadeh, A.UNSPECIFIED
Kebria, M. M.UNSPECIFIED
Keywords: Antioxidant Fertility Oxidative stress Reactive oxygen species Sperm alpha tocopherol ascorbic acid bilirubin carotenoid catalase ceruloplasmin glutathione glutathione peroxidase haptoglobin hemopexin reactive oxygen metabolite reduced nicotinamide adenine dinucleotide phosphate dehydrogenase superoxide dismutase thioredoxin transferrin ubiquinone urate antioxidant activity apoptosis DNA damage human leukocytospermia lipid peroxidation male male fertility male genital tract inflammation male infertility mortality Review spermatogenesis spermatozoon abnormality spermatozoon maturation spermatozoon motility
Divisions:
Page Range: pp. 791-796
Journal or Publication Title: Research Journal of Pharmacy and Technology
Journal Index: Scopus
Volume: 11
Number: 2
Identification Number: https://doi.org/10.5958/0974-360X.2018.00150.6
ISSN: 09743618 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1238

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