Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Prevalence of OmpK35 and OmpK36 porin expression in beta-lactamase and non-betalactamase- producing Klebsiella pneumoniae

Mon Nov 28 14:45:08 2022

(2012) Prevalence of OmpK35 and OmpK36 porin expression in beta-lactamase and non-betalactamase- producing Klebsiella pneumoniae. Biologics : targets & therapy. pp. 1-4. ISSN 1177-5491 (Electronic) 1177-5475 (Linking)

Full text not available from this repository.

Official URL: https://www.ncbi.nlm.nih.gov/pubmed/22291461

Abstract

BACKGROUND: The aims of this study were to confirm the presence of OmpK35 and OmpK36 in extended-spectrum beta-lactamase-producing and nonextended-spectrum beta-lactamase-producing Klebsiella pneumoniae and to determine the relationship between porin expression and resistance to third-generation cephalosporins. METHODS: Fifty-two K. pneumoniae isolates were obtained and analyzed for extended-spectrum beta-lactamase and for OmpK35 and OmpK36. RESULTS: Twenty-two (42.3) isolates of K. pneumoniae were extended-spectrum beta-lactamase producers. The OmpK35 profile in K. pneumoniae producing extended-spectrum beta-lactamase showed the presence of porin protein in ceftazidime-sensitive K. pneumoniae (six isolates), and the OmpK36 profile in K. pneumoniae producing extended-spectrum beta-lactamase revealed isolates sensitive to cefotaxime (n = 8) and ceftriaxone (n = 6). All nonextended-spectrum beta-lactamase-producing K. pneumoniae showed the presence of OmpK35 and OmpK36 porin proteins. CONCLUSION: The presence of OmpK35 is mostly related to ceftazidime susceptibility and less to cefotaxime and ceftriaxone susceptibility, while OmpK36 expression is seen more often in cefotaxime-sensitive isolates. OmpK35 and OmpK36 indicate nonextended-spectrum beta-lactamase producing strains, and their presence is important when selecting an antimicrobial agent.

Item Type: Article
Creators:
CreatorsEmail
Shakib, P.UNSPECIFIED
Ghafourian, S.UNSPECIFIED
Zolfaghary, M. R.UNSPECIFIED
Hushmandfar, R.UNSPECIFIED
Ranjbar, R.UNSPECIFIED
Sadeghifard, N.UNSPECIFIED
Keywords: Klebsiella pneumoniae extended-spectrum beta-lactamase producing strains porin expression
Divisions:
Page Range: pp. 1-4
Journal or Publication Title: Biologics : targets & therapy
Journal Index: Pubmed
Volume: 6
Identification Number: https://doi.org/10.2147/BTT.S27582
ISSN: 1177-5491 (Electronic) 1177-5475 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1192

Actions (login required)

View Item View Item