Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

In vitro and in vivo antibacterial activity of acorn herbal extract against some Gram-negative and Gram-positive bacteria

Sat Jun 25 08:48:46 2022

(2011) In vitro and in vivo antibacterial activity of acorn herbal extract against some Gram-negative and Gram-positive bacteria. Roumanian archives of microbiology and immunology. pp. 149-52. ISSN 1222-3891 (Print) 1222-3891 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/22568261

Abstract

BACKGROUND: The search for safe and effective antimicrobial agents, which treat, therapeutically and prophylactically, a wide variety of bacterial infections still represents a top priority for the biomedical field. This study was undertaken to investigate the antimicrobial properties of herbal extract (acorn) against bacterial pathogens in intestinal tract infections in in vitro and in vivo conditions and to study the effect of herbal extracts against bacteria in comparison with current antibiotics. FINDINGS: Ethanol extraction of acorn herb (Jaft) were evaluated against Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus, Salmonella typhi and Pseudomonas aeroginosa in in vitro and in vivo conditions. Minimal Inhibitory Concentration (MIC) was 10 microg/ml, 10 microg/ml, 5 microg/ml, 15 microg/ml and 15 microg/ml for K. pneumoniae, E. coli, S. typhi, S. aureus and P. aeroginosa, respectively. The in vivo results showed that the experimental infection produced by K. pneumoniae, E. coli, S. typhi and P. aeroginosa was totally inhibited in rats treated by the acorn extraction, while positive control rats died after five days. CONCLUSION: The finding revealed that acorn extract has great potential as antimicrobial compounds against pathogenic microorganisms. Thus, acorn extract can be used in the treatment of infectious diseases caused by resistant bacteria.

Item Type: Article
Creators:
CreatorsEmail
Mohebi, R.UNSPECIFIED
Ghafourian, S.UNSPECIFIED
Sekawi, Z.UNSPECIFIED
Khosravi, A.UNSPECIFIED
Galehdari, E. A.UNSPECIFIED
Hushmandfar, R.UNSPECIFIED
Ranjbar, R.UNSPECIFIED
Maleki, A.UNSPECIFIED
Mohammadzadeh, M.UNSPECIFIED
Rahbar, M.UNSPECIFIED
Sadeghifard, N.UNSPECIFIED
Keywords: Animals Anti-Bacterial Agents/*pharmacology Bacterial Infections/drug therapy Female Gram-Negative Bacteria/*drug effects Gram-Positive Bacteria/*drug effects Microbial Sensitivity Tests Plant Extracts/*pharmacology *Quercus Rats
Divisions:
Page Range: pp. 149-52
Journal or Publication Title: Roumanian archives of microbiology and immunology
Journal Index: Pubmed
Volume: 70
Number: 4
ISSN: 1222-3891 (Print) 1222-3891 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1190

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