Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Relationship between the Presence of the nalC Mutation and Multidrug Resistance in Pseudomonas aeruginosa

Mon Dec 4 10:10:03 2023

(2012) Relationship between the Presence of the nalC Mutation and Multidrug Resistance in Pseudomonas aeruginosa. International journal of microbiology. p. 575193. ISSN 1687-9198 (Electronic)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/22611402

Abstract

Objectives. The current study was conducted to determine the relationship between the presences of significant multidrug resistance in Pseudomonas aeruginosa (P. aeruginosa) having intact mexR genes (nalC) to different antibiotics. Methods. In order to identify nalC, fifty strains of P. aeruginosa were obtained. All isolates were found in urinary tract infections. They were evaluated against different antibiotics. The nalC mutant was identified by PCR. Results. The 50 clinical isolates of P. aeruginosa originated from two hospitals in Iran, in which 32 isolates were found in Milad hospital, and 18 isolates were collected in the Ilam Hospital. The results in Milad hospital of nalC revealed that all P. aeruginosa resistant to oxacillin showed the presence of nalC. In Ilam hospital only three (16.6) isolates were resistant to oxacilin and aztreonam, and among these three isolates only one isolate revealed resistance to ceftazidime and amikacin. The resistant isolates showed the presence of both OXA-10 and nalC. Conclusion. Our results showed that the presence of nalC was observed among P. aeruginosa resistance to oxacilin. Thus, the finding suggested relationship between oxacilin resistance and presence of nalC and consequently overproduction of the MexABOprM efflux system.

Item Type: Article
Creators:
CreatorsEmail
Sadeghifard, N.UNSPECIFIED
Valizadeh, A.UNSPECIFIED
Zolfaghary, M. R.UNSPECIFIED
Maleki, M. H.UNSPECIFIED
Maleki, A.UNSPECIFIED
Mohebi, R.UNSPECIFIED
Ghafourian, S.UNSPECIFIED
Khosravi, A.UNSPECIFIED
Divisions:
Page Range: p. 575193
Journal or Publication Title: International journal of microbiology
Journal Index: Pubmed
Volume: 2012
Identification Number: https://doi.org/10.1155/2012/575193
ISSN: 1687-9198 (Electronic)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1188

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