Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Gastric cardia adenocarcinoma pathway analysis

Mon May 27 07:36:07 2024

(2013) Gastric cardia adenocarcinoma pathway analysis. Gastroenterology and hepatology from bed to bench. S11-8. ISSN 2008-2258 (Print) 2008-2258 (Linking)

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Gastric cardia adenocarcinoma (GCA)is one of the few malignancies with unexplained reasons that have increased sharply in developed countries. The purpose of this review was to determine the pathways in GCA to identify new biomarker. So by comparing gene expression in GCA group with normal control identified important pathways. Gene expression data were extracted from the beforehand investigations then differentially expressed genes utilized in DAVID program to explorer and find related pathways. Our findings contain 367 gene names. Out of these 367 proteins, 199 were found to be exclusively expressed in GCA; whereas 168 proteins were detected down-regulated or silenced. The GCA associated diseases based on the differently expressed genes made up of diseases pathway related colorectal cancer, small cell lung cancer, breast cancer and H. pylori infection stomach cancer. KEGG pathways related to GCA contained cell cycle, p53 signaling pathway, DNA replication, toll-like receptor signaling pathway and some other diseases. The GO-discovered categories also demonstrated most biological process and molecular function related to cancer. Up until now, there is no report to introduce influential biomarkers in GCA so, the deregulated genes identified in GCA patterns might be helpful for diagnosis, prognosis and therapies for gastric cancer but validation of these biomarkers is necessary.

Item Type: Article
Rezaei-Tavirani, M.UNSPECIFIED
Rezaei-Tavirani, M.UNSPECIFIED
Keywords: Biomarker Gastric cardia adenocarcinoma Pathway
Page Range: S11-8
Journal or Publication Title: Gastroenterology and hepatology from bed to bench
Journal Index: Pubmed
Volume: 6
Number: Suppl
ISSN: 2008-2258 (Print) 2008-2258 (Linking)
Depositing User: مهندس مهدی شریفی

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