Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Functionalization of MWNT-COOH by one-step reaction with (3-oxoindolin-2-ylidene) urea and in vitro antitumor study on gastric cancer

Sun Aug 14 02:41:08 2022

(2013) Functionalization of MWNT-COOH by one-step reaction with (3-oxoindolin-2-ylidene) urea and in vitro antitumor study on gastric cancer. Gastroenterology and hepatology from bed to bench. S39-44. ISSN 2008-2258 (Print) 2008-2258 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/24834286

Abstract

AIM: In this study, we was tried to prepare a nano compound with a new way in functionalization as anti gastric cancer candidate. BACKGROUND: Functionalization of nanotubes is a useful route for modification of their biologic properties. (3-oxoindolin-2-ylidene) urea is a chemical compound that made of isatin and urea that can be useful in cancer study. PATIENTS AND METHODS: MWNT-COOH was functionalized by this compound with one-step reaction that is a new class in modification. Product has been investigated by FT-IR, Raman and SEM. Anti cancer investigation with human gastric cells and MTT assay test for measurement of viable cell numbers were also performed. RESULTS: The two bands at around 2800-2900 cm(-1) which are seen in functionalized product are attributed to the CH stretching of MWNT-COOH defects. CONCLUSION: Cellular results demonstrated that the functionalized nano-tube is a more toxic agent compared to other samples for cancer cells and can be used as a candidate material for chemotherapy.

Item Type: Article
Creators:
CreatorsEmail
Heidari-Keshel, S.UNSPECIFIED
Entezari, M.UNSPECIFIED
Rezaei-Tavirani, M.UNSPECIFIED
Ebrahimi, M.UNSPECIFIED
Rezaei-Tavirani, M.UNSPECIFIED
Keywords: Anti cancer Functionalization Mtt One-pot reaction
Divisions:
Page Range: S39-44
Journal or Publication Title: Gastroenterology and hepatology from bed to bench
Journal Index: Pubmed
Volume: 6
Number: Suppl
ISSN: 2008-2258 (Print) 2008-2258 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1180

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