(2013) Functionalization of MWNT-COOH by one-step reaction with (3-oxoindolin-2-ylidene) urea and in vitro antitumor study on gastric cancer. Gastroenterology and hepatology from bed to bench. S39-44. ISSN 2008-2258 (Print) 2008-2258 (Linking)
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Abstract
AIM: In this study, we was tried to prepare a nano compound with a new way in functionalization as anti gastric cancer candidate. BACKGROUND: Functionalization of nanotubes is a useful route for modification of their biologic properties. (3-oxoindolin-2-ylidene) urea is a chemical compound that made of isatin and urea that can be useful in cancer study. PATIENTS AND METHODS: MWNT-COOH was functionalized by this compound with one-step reaction that is a new class in modification. Product has been investigated by FT-IR, Raman and SEM. Anti cancer investigation with human gastric cells and MTT assay test for measurement of viable cell numbers were also performed. RESULTS: The two bands at around 2800-2900 cm(-1) which are seen in functionalized product are attributed to the CH stretching of MWNT-COOH defects. CONCLUSION: Cellular results demonstrated that the functionalized nano-tube is a more toxic agent compared to other samples for cancer cells and can be used as a candidate material for chemotherapy.
| Item Type: | Article | ||||||||||||
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| Keywords: | Anti cancer Functionalization Mtt One-pot reaction | ||||||||||||
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| Page Range: | S39-44 | ||||||||||||
| Journal or Publication Title: | Gastroenterology and hepatology from bed to bench | ||||||||||||
| Journal Index: | Pubmed | ||||||||||||
| Volume: | 6 | ||||||||||||
| Number: | Suppl | ||||||||||||
| ISSN: | 2008-2258 (Print) 2008-2258 (Linking) | ||||||||||||
| Depositing User: | مهندس مهدی شریفی | ||||||||||||
| URI: | http://eprints.medilam.ac.ir/id/eprint/1180 |
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