Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Protective Effect of Gastric Distension Preconditioning on Renal Ischemia/Reperfusion Injury in Rats

Thu May 23 04:18:33 2024

(2018) Protective Effect of Gastric Distension Preconditioning on Renal Ischemia/Reperfusion Injury in Rats. Indian Journal of Nephrology. pp. 113-118. ISSN 0971-4065

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Abstract

The stomach mechanoreceptors can be stimulated by gastric distension (GD) and through afferent vagal nerve, increased activity of the renal sympathetic pathways. Because renal sympathectomy can abolish the protective effect of ischemic preconditioning, it seems that GD preconditioning can be effective in renal ischemia/reperfusion (I/R) injury. Gastric inflate (8 ml of 37 degrees C water for 20 min) by a latex balloon inserted into the stomach through the fundus; I/R group was subjected to 45 min of bilateral ischemia and 24 h of reperfusion. GD preconditioning decreases blood urea nitrogen, creatinine, kidney damage score, and alkaline phosphatase levels compared to the sham GD group (P < 0.05). GD preconditioning may protect renal I/R injury through anti-inflammatory activity, but this efficacy requires extensive studies on the methods and mechanisms.

Item Type: Article
Creators:
CreatorsEmail
Malek, M.UNSPECIFIED
Maleki, M.UNSPECIFIED
Keywords: Gastric distension ischemia/reperfusion preconditioning renal serum alkaline-phosphatase acute kidney injury nitric-oxide ischemia-reperfusion stomach mechanoreceptors activation pressure disease protein Urology & Nephrology
Divisions:
Page Range: pp. 113-118
Journal or Publication Title: Indian Journal of Nephrology
Journal Index: ISI
Volume: 28
Number: 2
Identification Number: https://doi.org/10.4103/ijn.IJN₃₄₂₁₆
ISSN: 0971-4065
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/118

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