Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

siRNA therapeutics in the treatment of diseases

Sun Aug 14 02:27:34 2022

(2013) siRNA therapeutics in the treatment of diseases. Therapeutic delivery. pp. 45-57. ISSN 2041-5990 (Print) 2041-5990 (Linking)

Full text not available from this repository.

Official URL: https://www.ncbi.nlm.nih.gov/pubmed/23323780

Abstract

siRNAs are a class of dsRNAs, 21-23 nucleotides in length, which are able to silence their target genes through enzymatic cleavage of target mRNA. The sequence-specific gene-silencing by siRNA can be used as a new therapeutic approach for treatment of a variety of diseases that are incurable by conventional drugs. Many efforts have been made to overcome the problems related to delivery, stability, off-target gene silencing and immunostimulatory effects of siRNA. Different studies have carried out done to improve in vitro and in vivo delivery of naked or formulated siRNAs. In this review, different aspects of using siRNA as a new class of drugs will be discussed.

Item Type: Article
Creators:
CreatorsEmail
Bakhtiyari, S.UNSPECIFIED
Haghani, K.UNSPECIFIED
Basati, G.UNSPECIFIED
Karimfar, M. H.UNSPECIFIED
Keywords: Adjuvants, Immunologic/pharmacology Animals Gene Silencing *Gene Transfer Techniques Humans RNA, Small Interfering/*administration & dosage/chemistry
Divisions:
Page Range: pp. 45-57
Journal or Publication Title: Therapeutic delivery
Journal Index: Pubmed
Volume: 4
Number: 1
Identification Number: https://doi.org/10.4155/tde.12.136
ISSN: 2041-5990 (Print) 2041-5990 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1177

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