(2013) siRNA therapeutics in the treatment of diseases. Therapeutic delivery. pp. 45-57. ISSN 2041-5990 (Print) 2041-5990 (Linking)
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Abstract
siRNAs are a class of dsRNAs, 21-23 nucleotides in length, which are able to silence their target genes through enzymatic cleavage of target mRNA. The sequence-specific gene-silencing by siRNA can be used as a new therapeutic approach for treatment of a variety of diseases that are incurable by conventional drugs. Many efforts have been made to overcome the problems related to delivery, stability, off-target gene silencing and immunostimulatory effects of siRNA. Different studies have carried out done to improve in vitro and in vivo delivery of naked or formulated siRNAs. In this review, different aspects of using siRNA as a new class of drugs will be discussed.
| Item Type: | Article | ||||||||||
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| Keywords: | Adjuvants, Immunologic/pharmacology Animals Gene Silencing *Gene Transfer Techniques Humans RNA, Small Interfering/*administration & dosage/chemistry | ||||||||||
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| Page Range: | pp. 45-57 | ||||||||||
| Journal or Publication Title: | Therapeutic delivery | ||||||||||
| Journal Index: | Pubmed | ||||||||||
| Volume: | 4 | ||||||||||
| Number: | 1 | ||||||||||
| Identification Number: | https://doi.org/10.4155/tde.12.136 | ||||||||||
| ISSN: | 2041-5990 (Print) 2041-5990 (Linking) | ||||||||||
| Depositing User: | مهندس مهدی شریفی | ||||||||||
| URI: | http://eprints.medilam.ac.ir/id/eprint/1177 |
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