Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Her2/neu Expression in Wilms' Tumor and Correlation With Histopathologic Findings

Sun May 26 11:53:42 2024

(2013) Her2/neu Expression in Wilms' Tumor and Correlation With Histopathologic Findings. Iranian Journal of Cancer Prevention. pp. 160-4. ISSN 2008-2398 (Print) 2008-2398 (Linking)

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BACKGROUND: Wilms' tumor is an emberyonal tumor arising from remnants of immature renal tissue. Her2/neu is an onco-protein which mediates cellular proliferation, differentiation and survival. METHODS: In the current study, we analyzed Her2/neu expression in 40 Wilms' tumors. The clinico-demographic data of 40 patients with Wilms' tumor were retrieved. Immunohistochemical staining for HER2/neu was performed. Her2/neuimmunoreactivity was evaluated by Canadian Consensus 2007 scoring system. RESULTS: Among the 38 specimens with epithelial component, 68.5 were positive for Her2/neu, whereas there was immunoreactivity in 37 of 38 blastemal, and 12 of 31 stromal components. The Her2/neu expression was significantly higher in early stages (81.5) than in advanced stages (36.4) in epithelial component, but not in other components. CONCLUSION: This study suggested that Her2/neuexpression is associated with epithelial cell differentiation accompanied by lower stages of tumor. No significant relationship was found between Her2/neu positivity and tumor size and patient's age and gender.

Item Type: Article
Azizi Jalilian, F.UNSPECIFIED
Rezaei-Tavirani, M.UNSPECIFIED
Keywords: Her2/neu Nephroblastoma Tumor component Wilms' tumor
Page Range: pp. 160-4
Journal or Publication Title: Iranian Journal of Cancer Prevention
Journal Index: Pubmed
Volume: 6
Number: 3
ISSN: 2008-2398 (Print) 2008-2398 (Linking)
Depositing User: مهندس مهدی شریفی

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