Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Adenosine and adenosine receptors in the immunopathogenesis and treatment of cancer

Tue Jun 18 12:03:51 2024

(2018) Adenosine and adenosine receptors in the immunopathogenesis and treatment of cancer. Journal of Cellular Physiology. pp. 2032-2057. ISSN 0021-9541

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Tumor cells overcome anti-tumor responses in part through immunosuppressive mechanisms. There are several immune modulatory mechanisms. Among them, adenosine is an important factor which is generated by both cancer and immune cells in tumor microenvironment to suppress anti-tumor responses. Two cell surface expressed molecules including CD73 and CD39 catalyze the generation of adenosine from adenosine triphosphate (ATP). The generation of adenosine can be enhanced under metabolic stress like tumor hypoxic conditions. Adenosine exerts its immune regulatory functions through four different adenosine receptors (ARs) including A1, A2A, A2B, and A3 which are expressed on various immune cells. Several studies have indicated the overexpression of adenosine generating enzymes and ARs in various cancers which was correlated with tumor progression. Since the signaling of ARs enhances tumor progression, their manipulation can be promising therapeutic approach in cancer therapy. Accordingly, several agonists and antagonists against ARs have been designed for cancer therapy. In this review, wewill try to clarify the role of different ARs in the immunopathogenesis, as well as their role in the treatment of cancer.

Item Type: Article
Hojjat-Farsangi, M.UNSPECIFIED
Ghalamfarsa, G.UNSPECIFIED
Jadidi-Niaragh, F.UNSPECIFIED
Keywords: adenosine adenosine receptors cancer immunopathogenesis treatment endothelial growth-factor cl-ib-meca cell-cycle arrest human-melanoma cells nf-kappa-b cd8(+) t-cells chitosan-lactate nanoparticles chronic lymphocytic-leukemia colon adenocarcinoma cells activated protein-kinase Cell Biology Physiology
Page Range: pp. 2032-2057
Journal or Publication Title: Journal of Cellular Physiology
Journal Index: ISI
Volume: 233
Number: 3
Identification Number:
ISSN: 0021-9541
Depositing User: مهندس مهدی شریفی

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