Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Therapeutic Effects of Laser on Partial Osteotomy in the Rat Model of Hypothyroidism

Thu Mar 28 15:46:45 2024

(2018) Therapeutic Effects of Laser on Partial Osteotomy in the Rat Model of Hypothyroidism. Journal of Lasers in Medical Sciences. pp. 121-127. ISSN 2008-9783

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Abstract

Introduction: Several experimental studies have displayed positive result for laser radiation on stimulating bone regeneration in recent years. The purpose of this experimental study was to determine low-level laser (LLL) effects on partial bone defects in hypothyroidism male rat. Methods: Forty male Wistar rats were randomly distributed as below groups: hypothyroidism + laser (Hypo + laser), hypothyroidism (Hypo), and control. Four weeks after surgery, the tibia bone was removed. Biomechanical and histological examinations were performed immediately. Results: Our results showed significant reduction in the absorption of energy, resistance in bending deformation (bending stiffness), maximum force, high stress load, trabecular bone volume, and number of osteocytes, osteoblasts and osteoclasts in the osteotomy site in hypothyroidism rats compared to hypothyroidism + laser group (P < 0.05). Conclusion: The results indicated that using laser may improve fracture regeneration and it may accelerate bone healing in hypothyroidism rat.

Item Type: Article
Creators:
CreatorsEmail
Sefati, N.UNSPECIFIED
Abbaszadeh, H. A.UNSPECIFIED
Fathabady, F. F.UNSPECIFIED
Abdollahifar, M. A.UNSPECIFIED
Amini, A.UNSPECIFIED
Noori-Zadeh, A.UNSPECIFIED
Darabi, S.UNSPECIFIED
Norouzian, M.UNSPECIFIED
Keywords: Hypothyroidism Low-level laser Partial osteotomy mesenchymal stem-cells oligodendrocyte-like cells conditioned medium bone repair expression triiodothyronine hyperthyroidism differentiation alpha nm Radiology, Nuclear Medicine & Medical Imaging
Divisions:
Page Range: pp. 121-127
Journal or Publication Title: Journal of Lasers in Medical Sciences
Journal Index: ISI
Volume: 9
Number: 2
Identification Number: https://doi.org/10.15171/jlms.2018.23
ISSN: 2008-9783
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/113

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