Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Association between adipokine and myeloperoxidase levels in patients with coronary artery disease

Wed Nov 30 08:37:50 2022

(2015) Association between adipokine and myeloperoxidase levels in patients with coronary artery disease. Acta medica Iranica. pp. 25-9. ISSN 1735-9694 (Electronic) 0044-6025 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/25597601

Abstract

The adipokines, leptin and adiponectin, have a prominent role in the pathogenesis of coronary artery disease (CAD). The inflammatory enzyme, myeloperoxidase (MPO) also has an important role in the pathogenesis of CAD. Association of the adipokines with MPO remains to be resolved in patients with CAD. In this case-control study, 100 patients with CAD and 100 control subjects were appropriately recruited. Angiographic evaluation assigned the presence of CAD. Plasma leptin, adiponectin and MPO concentrations were measured using immunoassay methods. Other conventional cardiovascular risk factors were also recorded. Leptin and MPO concentrations were significantly increased in CAD patients compared to control subjects (25.38 +/- 5.91 ng/ml vs. 3.68 +/- 1.95 ng/mL and 52.85 +/- 12.90 ng/mL vs. 23.00 +/- 3.60 ng/mL, P=0.001, respectively). In contrast, adiponectin was significantly decreased in CAD patients compared to control subjects (5.62 +/- 1.15 microg/mL vs. 9.25 +/- 1.8, P = 0.001). There was a strong positive association between leptin and MPO concentrations only in CAD patients (P = 0.01). In contrast, a significant inverse association was found between adiponectin and MPO concentrations in CAD patients (P = 0.01). The associations also were significant after adjustment for other conventional risk factors (P = 0.001). Considering the presence of significant association between leptin and MPO, as well as adiponectin and MPO in patients with CAD, it may be inferred that the contribution of the adipokines in the pathogenesis of CAD may be, in part, through affecting the MPO concentration.

Item Type: Article
Creators:
CreatorsEmail
Basati, G.UNSPECIFIED
Emami Razavi, A.UNSPECIFIED
Abdi, S.UNSPECIFIED
Sarrafzadegan, N.UNSPECIFIED
Keywords: Adipokines/*blood Biomarkers/blood Coronary Artery Disease/*blood/epidemiology Enzyme-Linked Immunosorbent Assay Female Follow-Up Studies Humans Iran/epidemiology Male Middle Aged Peroxidase/*blood Prevalence Retrospective Studies Risk Factors
Divisions:
Page Range: pp. 25-9
Journal or Publication Title: Acta medica Iranica
Journal Index: Pubmed
Volume: 53
Number: 1
ISSN: 1735-9694 (Electronic) 0044-6025 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1114

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