Repository of Research and Investigative Information

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Ilam University of Medical Sciences

High Incidence of Macrolide and Tetracycline Resistance among Streptococcus Agalactiae Strains Isolated from Clinical Samples in Tehran, Iran

Mon Aug 8 17:04:04 2022

(2014) High Incidence of Macrolide and Tetracycline Resistance among Streptococcus Agalactiae Strains Isolated from Clinical Samples in Tehran, Iran. Maedica. pp. 157-61. ISSN 1841-9038 (Print) 1841-9038 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/25705271

Abstract

BACKGROUND: Streptococcus agalactiae or Group B Streptococci (GBS) is an important bacterial pathogen that causes a wide range of infections including neonatal sepsis, meningitis, pneumonia and soft tissue or urinary tract infections. MATERIAL AND METHODS: One hundred and fifteen isolates of Streptococcus agalactiae collected from urine specimens of patients attending a hospital in Tehran. All isolates were screened for their capsular types and genes encoding resistance to the macrolide and tetracycline antibiotics by PCR and multiplex PCR-based methods. RESULTS: Most of isolates belonged to capsular types III (49), V (19), II (16), and Ib (6). Twelve isolates (10) were nontypable. All isolates were susceptible to penicillin and Quinupristin-dalfopristin, but were resistant to clindamycin (35), chloramphenicol (45), erythromycin (35), linezolid (1) and tetracycline (96). The most prevalent antimicrobial resistance gene was tetM found in 93 of the isolates followed by ermTR, ermB, and tetK, found in 23, 16, and 16 of isolates, respectively. The genes, tetL, tetO, ermA, ermC and mefA were not detected in any of the S. agalactiae isolates. Of the 110 tetracycline resistant S. agalactiae, 89 isolates harbored the tetM gene alone and eighteen isolates carried the tetM gene with the tetK gene. All erythromycin-resistant isolates exhibited cMLSB resistance phenotype, 22 isolates harbored the ermTR gene alone and five isolates carried the ermTR gene with the ermB gene. The rate of coexistence of genes encoding the erythromycin and tetracycline resistance determinants was 34. CONCLUSION: The present study demonstrated that S. agalactiae isolates obtained from urine samples showed a high rate of resistance to tetracycline, chloramphenicol and macrolide antibiotics and were commonly associated with the resistance genes temM, ermTR or ermB.

Item Type: Article
Creators:
CreatorsEmail
Emaneini, M.UNSPECIFIED
Mirsalehian, A.UNSPECIFIED
Beigvierdi, R.UNSPECIFIED
Fooladi, A. A.UNSPECIFIED
Asadi, F.UNSPECIFIED
Jabalameli, F.UNSPECIFIED
Taherikalani, M.UNSPECIFIED
Keywords: Streptococcus agalactiae capsular type ermTR tetM
Divisions:
Page Range: pp. 157-61
Journal or Publication Title: Maedica
Journal Index: Pubmed
Volume: 9
Number: 2
ISSN: 1841-9038 (Print) 1841-9038 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1110

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