Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Impact of melatonin supplementation in the rat spermatogenesis subjected to forced swimming exercise

Mon Jun 27 09:29:28 2022

(2018) Impact of melatonin supplementation in the rat spermatogenesis subjected to forced swimming exercise. Andrologia. p. 9. ISSN 0303-4569

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Abstract

Oxygen consumption increases many times during exercise, which can increase reactive oxygen species. It negatively affects fertility in male athletes. Melatonin is exerting a regulatory role at different levels of the hypothalamic-pituitary-gonadal axis. However, there is no evidence that the protective effects of melatonin persist after long duration exercise on the spermatogenesis. Therefore, this study was conducted to examine the impacts of melatonin on the testis following the administration of swimming exercise. Rats were separated into five different groups, including Control, sham M: received the solvent of melatonin, M: received melatonin, S: the exercise protocol, MS: received melatonin and the exercise protocol. After 8weeks, animals were scarified and antioxidant enzymes levels of testes, spermatogenic cells apoptosis and sperm quality were measured. Swimming decreased all parameters of spermatozoa. Nevertheless, melatonin could significantly improve the progressive motility of spermatozoa in MS rats. Swimming caused an increased apoptosis of S group and decreased all antioxidant enzymes. Melatonin could drastically reduce apoptosis and increased these enzymes. Therefore, melatonin seems to induce the production of antioxidant enzymes of testicular tissues and diminish the extent of apoptotic changes caused by forced exercise on the testis, which can, in turn, ameliorate the sperm parameters.

Item Type: Article
Creators:
CreatorsEmail
Moayeri, A.UNSPECIFIED
Mokhtari, T.UNSPECIFIED
Hedayatpour, A.UNSPECIFIED
Abbaszadeh, H. A.UNSPECIFIED
Mohammadpour, S.UNSPECIFIED
Ramezanikhah, H.UNSPECIFIED
Shokri, S.UNSPECIFIED
Keywords: melatonin spermatogenesis swimming exercise oxidative stress reactive oxygen nandrolone decanoate physical-activity skeletal-muscle damage testis generation secretion responses Endocrinology & Metabolism
Divisions:
Page Range: p. 9
Journal or Publication Title: Andrologia
Journal Index: ISI
Volume: 50
Number: 3
Identification Number: https://doi.org/10.1111/and.12907
ISSN: 0303-4569
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/111

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