Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Coenzyme Q10 in combination with triple therapy regimens ameliorates oxidative stress and lipid peroxidation in chronic gastritis associated with H. pylori infection

Mon Oct 3 02:11:19 2022

(2015) Coenzyme Q10 in combination with triple therapy regimens ameliorates oxidative stress and lipid peroxidation in chronic gastritis associated with H. pylori infection. Journal of Clinical Pharmacology. pp. 842-7. ISSN 1552-4604 (Electronic) 0091-2700 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/25854786

Abstract

Chronic gastritis associated with H. pylori infection causes oxidative stress in the stomach. This study aimed to evaluate the therapeutic effects of coenzyme q10 among gastric patients infected by H. pylori. By a clinical trial, chronic gastric patients infected by H. pylori were randomly divided into 2 groups: intervention and placebo. The placebo group received a standard triple therapy regimen, and the intervention group received the triple regimen + coenzyme Q10 (CoQ10). Mean inflammation score; serum levels of 3 serum markers were then compared. A total of 100 participants of whom 67 were female were evaluated. The mean age of participants was 59.4 +/- 11.4 years. The mean inflammation score was considerably decreased at the end of the study, in the intervention group. The mean levels of total antioxidant capacity (TAC) and glutathione peroxidase (GPx) at the end of the study were reduced among the triple therapy group (P < .05, P =.03 respectively). The mean levels of TAC and GPx were significantly higher among the intervention group at the end of the study compared with those at the start of the study. The combination of triple therapy with CoQ10 demonstrated an effective outcome on the mucosal inflammation, and stress oxidative in patients with chronic gastritis.

Item Type: Article
Creators:
CreatorsEmail
Rahmani, A.UNSPECIFIED
Abangah, G.UNSPECIFIED
Moradkhani, A.UNSPECIFIED
Hafezi Ahmadi, M. R.UNSPECIFIED
Asadollahi, K.UNSPECIFIED
Keywords: Aged Anti-Bacterial Agents/pharmacology/*therapeutic use Anti-Ulcer Agents/pharmacology/*therapeutic use Antioxidants/pharmacology/*therapeutic use Double-Blind Method Drug Therapy, Combination Female Gastritis/blood/*drug therapy Glutathione Peroxidase/blood Helicobacter Infections/blood/*drug therapy Helicobacter pylori Humans Lipid Peroxidation/drug effects Male Malondialdehyde/blood Metronidazole/pharmacology/therapeutic use Middle Aged Organometallic Compounds/pharmacology/therapeutic use Oxidative Stress/drug effects Tetracycline/pharmacology/therapeutic use Ubiquinone/*analogs & derivatives/pharmacology/therapeutic use H. pylori chronic gastritis coenzyme Q10 (CoQ10) glutathione peroxidase (GPx) inflammation malondialdehyde (MDA) total antioxidant capacity (TAC)
Divisions:
Page Range: pp. 842-7
Journal or Publication Title: Journal of Clinical Pharmacology
Journal Index: Pubmed
Volume: 55
Number: 8
Identification Number: https://doi.org/10.1002/jcph.508
ISSN: 1552-4604 (Electronic) 0091-2700 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1100

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