Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Effects of Fenugreek Seed Extract and Swimming Endurance Training on Plasma Glucose and Cardiac Antioxidant Enzymes Activity in Streptozotocin-induced Diabetic Rats

Sat Jun 25 08:35:49 2022

(2015) Effects of Fenugreek Seed Extract and Swimming Endurance Training on Plasma Glucose and Cardiac Antioxidant Enzymes Activity in Streptozotocin-induced Diabetic Rats. Osong public health and research perspectives. pp. 87-93. ISSN 2210-9099 (Print) 2210-9099 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/25938017

Abstract

OBJECTIVE: Diabetes mellitus is a group of metabolic diseases characterized by chronic hyperglycemia condition resulting from defective insulin secretion or resistance insulin action, or both. The purpose of this study was to evaluate the effect of 6 weeks swimming training and Trigonella foenum-graecum seed (fenugreek) extract, alone and in combination, on plasma glucose and cardiac antioxidant enzyme activity of streptozotocin-induced diabetic rats. METHODS: Fifty male Wistar rats were divided into five groups: diabetic control (DC, n = 8); healthy control (HC, n = 11); swimming training (S, n = 11); swimming training + fenugreek seed extract (1.74 g/kg body weight; SF1, n = 11); and swimming training + fenugreek seed extract (0.87 g/kg body weight; SF2, n = 9). Streptozotocin was used for the induction of diabetes. Results were analyzed using one-way analysis of variance followed by Tukey test. RESULTS: In comparison with the DC group, all groups exhibited a significant decrease in body weight (p < 0.05), except for the HC group. SF1 and HC groups showed significant decreases in plasma glucose levels compared with the DC group (p < 0.05). S, SF1, SF2, and HC groups showed significant elevations in cardiac antioxidant enzymes activity in comparison with the DC group. CONCLUSION: The results indicated that the combination of endurance swimming training and fenugreek seed extract can significantly reduce the plasma glucose levels and increase cardiac antioxidant enzymes activity in diabetic rats. Our findings suggest that this combination could be useful for the treatment of hyperglycemia and cardiac oxidative stress induced by diabetes mellitus.

Item Type: Article
Creators:
CreatorsEmail
Arshadi, S.UNSPECIFIED
Bakhtiyari, S.UNSPECIFIED
Haghani, K.UNSPECIFIED
Valizadeh, A.UNSPECIFIED
Keywords: diabetes endurance fenugreek heart antioxidants swimming training
Divisions:
Page Range: pp. 87-93
Journal or Publication Title: Osong public health and research perspectives
Journal Index: Pubmed
Volume: 6
Number: 2
Identification Number: https://doi.org/10.1016/j.phrp.2014.12.007
ISSN: 2210-9099 (Print) 2210-9099 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1098

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