Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Precancerous histopathologic lesions of upper gastrointestinal tract among dyspeptic patients upon endoscopic evaluations

Thu May 23 03:44:14 2024

(2016) Precancerous histopathologic lesions of upper gastrointestinal tract among dyspeptic patients upon endoscopic evaluations. Journal of gastrointestinal cancer. pp. 1-7. ISSN 1941-6636 (Electronic)

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PURPOSE: Gastric cancer is one of the most important causes of morbidity and mortality worldwide which is influenced by different risk factors. This study aimed to investigate the effects of various factors associated with precancerous lesions among dyspeptic patients. METHODS: Among dyspeptic patients admitted to gastrointestinal clinics in Ilam city, west of Iran, 1123 were investigated during 2008 to 2011. All patients were evaluated by endoscopy and their biopsy samples were examined for histological differentiations and their pathology reports were classified according to Sydney criteria. RESULTS: One thousand out of 1123 admitted dyspeptic patients were finally analyzed. The mean age of participants was 48 years (ranged 21-84 years), and 64.8 of patients were male. The frequency of patients with atrophy, metaplasia, or both was 14.4, adenocarcinoma 1.2, and polyp hyperplasia 0.7, respectively. The highest frequency was related to those with chronic gastritis accompanied by Helicobacter pylori infection with a figure of 80.8. The frequency of precancerous lesions among smokers compared to non-smokers was higher significantly (p < 0.03). Though non-significant, BMI was associated with the higher risk of premalignant lesions among dyspeptic patients by an increasing manner. CONCLUSION: Chronic gastritis accompanied with H. pylori infection was revealed as the most prevalent variable among dyspeptic patients. Also, higher BMI compared to normal and smokers compared to non-smokers were more involved by precancerous lesions.

Item Type: Article
Hafezi-Ahmadi, M. R.UNSPECIFIED
Jaafari-Haidarlo, A.UNSPECIFIED
Keywords: Adult Aged Aged, 80 and over Dyspepsia/*complications/pathology Endoscopy/*methods Female Follow-Up Studies Gastritis/*epidemiology/pathology Helicobacter Infections/*epidemiology/pathology Helicobacter pylori/isolation & purification Humans Iran/epidemiology Male Middle Aged Neoplasm Staging Precancerous Conditions/*epidemiology/pathology Prevalence Prognosis Risk Factors Stomach Neoplasms/*epidemiology/pathology Upper Gastrointestinal Tract/*pathology Young Adult Dyspeptic patients Histopathologic lesions Precancerous Upper gastrointestinal tract
Page Range: pp. 1-7
Journal or Publication Title: Journal of gastrointestinal cancer
Journal Index: Pubmed
Volume: 47
Number: 1
Identification Number:
ISSN: 1941-6636 (Electronic)
Depositing User: مهندس مهدی شریفی

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