Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Survival rate of gastric cancer in Iran; a systematic review and meta-analysis

Thu Apr 25 02:16:23 2024

(2016) Survival rate of gastric cancer in Iran; a systematic review and meta-analysis. Gastroenterology and hepatology from bed to bench. pp. 78-86. ISSN 2008-2258 (Print) 2008-2258 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/27099666

Abstract

AIM: In this study, we aimed to estimate one- to five-year survival rates in Iranian patients with gastric cancer (GC). In addition, we preformed subgroup analyses and meta-regression to explore possible sources of heterogeneity between studies. BACKGROUND: According to literatures, there has been increasing attention to the long-term survival rate in patients with GC in Iran. However, results have been inconsistent and remain controversial in overall survival rates. PATIENTS AND METHODS: Literature searches were conducted using PubMed, Scopus, and ISI, as well as Magiran, Medlib, SID, and Iran Medex databases. Studies were pooled and summary one to five survival rates were calculated. Univariate and multivariate regression analyses were used to explore possible sources of heterogeneity among studies. Subgroup analyses were also conducted. Analyses were conducted using the STATA statistical software package. RESULTS: Final analysis of 29361 patients from 26 eligible studies was performed. The overall survival rate (one to five years) in all studies, by meta-analysis of 24, 14, 23, 12 and 22 studies were 52, 31, 24, 22, and 15, respectively. Meta-regression analysis showed an increase in one- and five-year survival rate over the time (Reg Coef = 0.016, p= 0.04) and (Reg Coef= 0.021, p= 0.049), respectively. Positive heterogeneity was observed between quality of papers and data sources (P<0.001). CONCLUSION: More than half of GC deaths happened in the first year at diagnosis, and another 30 plus they occurred during the second year after confirmed diagnosis. Our results admit lower survival rates in Iran, similar to other developing countries.

Item Type: Article
Creators:
CreatorsEmail
Veisani, Y.UNSPECIFIED
Delpisheh, A.UNSPECIFIED
Keywords: Gastric cancer Heterogeneityndrial Meta-analysis Survival rate Systematic review
Divisions:
Page Range: pp. 78-86
Journal or Publication Title: Gastroenterology and hepatology from bed to bench
Journal Index: Pubmed
Volume: 9
Number: 2
ISSN: 2008-2258 (Print) 2008-2258 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1075

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