Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Anti-biofilm Properties of Peganum harmala against Candida albicans

Mon Jun 27 09:24:13 2022

(2016) Anti-biofilm Properties of Peganum harmala against Candida albicans. Osong public health and research perspectives. pp. 116-8. ISSN 2210-9099 (Print) 2210-9099 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/27169010

Abstract

OBJECTIVES: Vaginitis still remains as a health issue in women. It is notable that Candida albicans producing biofilm is considered a microorganism responsible for vaginitis with hard to treat. Also, Peganum harmala was applied as an anti fungal in treatment for many infections in Iran. Therefore, this study goal to investigate the role of P. harmala in inhibition of biofilm formation in C. albicans. METHODS: So, 27 C. albicans collected from women with Vaginitis, then subjected for biofilm formation assay. P. harmala was applied as antibiofilm formation in C. albicans. RESULTS: Our results demonstrated that P. harmala in concentration of 12 mug/ml easily inhibited strong biofilm formation; while the concentrations of 10 and 6 mug/ml inhibited biofilm formation in moderate and weak biofilm formation C. albicans strains, respectively. CONCLUSION: Hence, the current study presented P. harmala as antibiofilm herbal medicine for C. albicans; but in vivo study suggested to be performed to confirm its effectiveness.

Item Type: Article
Creators:
CreatorsEmail
Aboualigalehdari, E.UNSPECIFIED
Sadeghifard, N.UNSPECIFIED
Taherikalani, M.UNSPECIFIED
Zargoush, Z.UNSPECIFIED
Tahmasebi, Z.UNSPECIFIED
Badakhsh, B.UNSPECIFIED
Rostamzad, A.UNSPECIFIED
Ghafourian, S.UNSPECIFIED
Pakzad, I.UNSPECIFIED
Keywords: Candida albicans Peganum harmala biofilm formation
Divisions:
Page Range: pp. 116-8
Journal or Publication Title: Osong public health and research perspectives
Journal Index: Pubmed
Volume: 7
Number: 2
Identification Number: https://doi.org/10.1016/j.phrp.2015.12.010
ISSN: 2210-9099 (Print) 2210-9099 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1072

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