Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Comparison of quinolone and beta-lactam resistance among Escherichia coli strains isolated from urinary tract infections

Wed Jun 29 10:27:05 2022

(2016) Comparison of quinolone and beta-lactam resistance among Escherichia coli strains isolated from urinary tract infections. Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive. pp. 326-330. ISSN 1124-9390 (Print) 1124-9390 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/28011969

Abstract

The growing frequency of antibiotic resistances is now a universal problem. Increasing resistance to new generations of beta-lactam and quinolone antibiotics in multidrug-resistant Enterobacteriaceae isolates is considered an emergency health issue worldwide. The aim of this study was to evaluate plasmid-mediated quinolone resistance genes in ESBL-producing Escherichia coli isolated from urinary tract infections (UTIs). In our study ESBL-producing isolates were assessed by screening methods. After determination of antimicrobial susceptibility testing, detection of ESBLs and quinolone resistance genes was performed. A total of 97 ESBL-producing E. coli were determined. The bla-TEM, bla-SHV and bla-CTX-M genes were detected in 90 isolates. The bla-TEM was the most frequently detected gene (46.4), followed by bla-SHV (31.9) and bla-CTX-M (14.4). The most prevalent quinolone resistance gene among ESBL-producing isolates was oqxAB which was found in 67 isolates (69.1). The frequencies of the aac(6')-Ib-cr, qnr and qepA were 65 (67), 8 (8.2) and 6 (6.2), respectively. Our data indicate that the prevalence of plasmid-mediated quinolone resistance genes in ESBL-positive isolates is increasing. The co-dissemination of PMQR and ESBL genes among E. coli isolates can be considered a threat to public health. Therefore, prescription of antibiotics against infectious disease should be managed carefully.

Item Type: Article
Creators:
CreatorsEmail
Tayebi, Z.UNSPECIFIED
Heidari, H.UNSPECIFIED
Kazemian, H.UNSPECIFIED
Ghafoori, S. M.UNSPECIFIED
Boroumandi, S.UNSPECIFIED
Houri, H.UNSPECIFIED
Keywords: *Anti-Bacterial Agents/pharmacology Cross-Sectional Studies Drug Resistance, Multiple, Bacterial/genetics Escherichia coli/*genetics/isolation & purification Escherichia coli Infections/*complications/epidemiology Genotype Hospitals/statistics & numerical data Humans Inpatients/statistics & numerical data Iran/epidemiology Microbial Sensitivity Tests Outpatients/statistics & numerical data Prevalence *Quinolones/pharmacology Urinary Tract Infections/epidemiology/*microbiology beta-Lactam Resistance/*genetics beta-Lactamases/analysis/*genetics *beta-Lactams/pharmacology
Divisions:
Page Range: pp. 326-330
Journal or Publication Title: Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive
Journal Index: Pubmed
Volume: 24
Number: 4
ISSN: 1124-9390 (Print) 1124-9390 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1056

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