Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

In vivo Antibacterial and Wound Healing Activities of Roman Chamomile (Chamaemelum nobile)

Wed Nov 30 07:37:23 2022

(2018) In vivo Antibacterial and Wound Healing Activities of Roman Chamomile (Chamaemelum nobile). Infectious disorders drug targets. pp. 41-45. ISSN 2212-3989 (Electronic) 1871-5265 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/28034365

Abstract

BACKGROUND: Today considerable number of drugs are produced from plants. Several plants with antibacterial and healing applications are used in medicine such as Roman chamomile (Chamaemelum nobile L.). Wound infection is one of the most prevalent infections among infectious diseases around the world. Due to appearance of drug resistance, researchers are now paying attention to medicinal plants. Therefore, this study was designed to investigate the antimicrobial and wound healing properties of C. nobile against Pseudomonas aeruginosa using in vivo conditions. METHODS: Ethanolic extract of C. nobile was provided using standard method. The 5 C. nobile ointment was prepared by dissolving lyophilized extract in eucerin. Forty five male rats were obtained from Ilam university. After anesthetization and wound creation, wounds were infected by P. aeruginosa. The rats were divided into three groups, group I was treated with C. nobile ointment, group II was treated with tetracycline ointment and the third group was treated with base gel as control group. RESULTS: Antibacterial and wound healing activities of C. nobile ointment were more than tetracycline ointment significantly. Our results indicated that extract of C. nobile had effective antibacterial activity and accelerated the progression of wound healing. CONCLUSION: Our study indicated that antibacterial and wound healing activities of C. nobile ointment were notable. C. nobile therapy in combination with antibiotics can also be useful because medicinal plants contents operate in synergy with antibiotics. These results revealed the value of plant extracts to control antibiotic resistant bacteria in wound infections.

Item Type: Article
Creators:
CreatorsEmail
Kazemian, H.UNSPECIFIED
Ghafourian, S.UNSPECIFIED
Sadeghifard, N.UNSPECIFIED
Houshmandfar, R.UNSPECIFIED
Badakhsh, B.UNSPECIFIED
Taji, A.UNSPECIFIED
Shavalipour, A.UNSPECIFIED
Mohebi, R.UNSPECIFIED
Ebrahim-Saraie, H. S.UNSPECIFIED
Houri, H.UNSPECIFIED
Heidari, H.UNSPECIFIED
Keywords: Administration, Topical Animals Anti-Bacterial Agents/administration & dosage/*therapeutic use Bacteria/*drug effects Chamaemelum/*chemistry Drug Synergism Male Phytotherapy Plant Extracts/administration & dosage/*therapeutic use Plants, Medicinal/chemistry Pseudomonas aeruginosa/drug effects Rats Tetracycline/administration & dosage/therapeutic use Wound Healing/*drug effects In vivo Pseudomonas aeruginosa antibacterial roman chamomile (Chamaemelum nobile) wound healing
Divisions:
Page Range: pp. 41-45
Journal or Publication Title: Infectious disorders drug targets
Journal Index: Pubmed
Volume: 18
Number: 1
Identification Number: https://doi.org/10.2174/1871526516666161230123133
ISSN: 2212-3989 (Electronic) 1871-5265 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1055

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