Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Do serum prolactin levels correlate with antibodies against desmoglein in pemphigus vulgaris?

Thu Oct 6 06:35:58 2022

(2016) Do serum prolactin levels correlate with antibodies against desmoglein in pemphigus vulgaris? Advanced biomedical research. p. 206. ISSN 2277-9175 (Print) 2277-9175 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/28217644

Abstract

BACKGROUND: Pemphigus vulgaris is a chronic inflammatory disease of skin, the etiology of which is not completely known. Despite the latter, anti-desmoglein antibodies play a proven role in the pathogenesis. Recent studies showed an etiologic effect for prolactin in the pemphigus vulgaris. This study aimed to quantify the correlation between serum prolactin levels and anti-desmoglein antibodies in patients with pemphigus vulgaris. MATERIALS AND METHODS: Prolactin and antibodies against desmoglein 1 and 3 measured with ELISA in 14 new subjects of pemphigus vulgaris. RESULTS: There was no statistically significant relation between both serum prolactin and anti-desmoglein1 levels (r = 0.02, P = 0.47) and serum prolactin and anti-desmoglein 3 levels (r= -0.09, P = 0.38). CONCLUSION: This study indicates that no correlation was found between serum prolactin levels and anti-desmoglein 1 levels and serum prolactin and anti-desmoglein 3 levels. However, other studies should be initiated regarding exact molecular and cellular effects of prolactin in the pathogenesis of pemphigus vulgaris.

Item Type: Article
Creators:
CreatorsEmail
Iraji, F.UNSPECIFIED
Tajmirriahi, N.UNSPECIFIED
Momeni, I.UNSPECIFIED
Jamshidi, K.UNSPECIFIED
Hashemzehi, F.UNSPECIFIED
Siadat, A. H.UNSPECIFIED
Esfahani, A. A.UNSPECIFIED
Keywords: Desmoglein pemphigus vulgaris prolactin
Divisions:
Page Range: p. 206
Journal or Publication Title: Advanced biomedical research
Journal Index: Pubmed
Volume: 5
Identification Number: https://doi.org/10.4103/2277-9175.191002
ISSN: 2277-9175 (Print) 2277-9175 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1045

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