Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Introducing crucial protein panel of gastric adenocarcinoma disease

Wed Jun 19 11:12:45 2024

(2017) Introducing crucial protein panel of gastric adenocarcinoma disease. Gastroenterology and hepatology from bed to bench. pp. 21-28. ISSN 2008-2258 (Print) 2008-2258 (Linking)

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AIM: Since interactome analysis of diseases can provide candidate biomarker panel related to the diseases, in this research, protein-protein interaction (PPI) network analysis is used to introduce the involved crucial proteins in Gastric adenocarcinoma (GA). BACKGROUND: Gastric adenocarcinoma (GA) is the most common type of stomach cancer. There is no efficient diagnostic molecular method for GA. METHOD: Applying Cytoscape software 3.4.0 and String Database, the PPI network was constructed for 200 genes. Based on centrality parameters, the critical nodes were screened. Gene ontology of the key proteins for pathway analysis and molecular function processing were done and the highlighted pathways and activities were discussed. RESULTS: Among 200 initial genes, 141 genes were included in a main connected network. Seven crucial proteins, including tumor protein p53, epidermal growth factor receptor, albumin, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian), v-akt murine thymoma viral oncogene homolog 1, v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) and catenin (cadherin-associated protein), beta 1, 88kDa, and Myogenic differentiation 1, were introduced as key nodes of the network. These identified proteins are mostly involved in pathways and activities related to cancer. CONCLUSION: In conclusion, the finding is corresponding to the significant roles of these introduced proteins in GA disease. This protein panel may be a useful probe in the management of GA.

Item Type: Article
Rezaei-Tavirani, M.UNSPECIFIED
Rezaei-Tavirani, M.UNSPECIFIED
Rostami-Nejad, M.UNSPECIFIED
Keywords: Biomarker panel Gastric adenocarcinoma Gene ontology Hub-bottleneck nodes Protein-protein interaction network
Page Range: pp. 21-28
Journal or Publication Title: Gastroenterology and hepatology from bed to bench
Journal Index: Pubmed
Volume: 10
Number: 1
ISSN: 2008-2258 (Print) 2008-2258 (Linking)
Depositing User: مهندس مهدی شریفی

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