Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Novel Information about Neisseria meningitidis: Identification of the Most Important Type II Toxin Antitoxin Systems

Wed Jul 17 18:07:33 2024

(2017) Novel Information about Neisseria meningitidis: Identification of the Most Important Type II Toxin Antitoxin Systems. Infectious disorders drug targets. pp. 81-85. ISSN 2212-3989 (Electronic) 1871-5265 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/28460613

Abstract

BACKGROUND: Toxin antitoxin systems is the one of the important elements among pathogenic bacteria which have proven roles such as biofilm formation, cell programmed death and persister cells formation. Neisseria meningitidis causing serious diseases in humans must be highlighted. OBJECTIVE: The current study aimed to identify the mazEF and relBE TA systems in N. meningitidis. METHOD: The potential TA loci were searched in RASTA database by bioinformatics analysis and then, experimental analysis was performed by PCR assay. PCR products were confirmed by sequencing. RESULTS: Our findings demonstrated that mazEF and relBE TA systems were positive by PCR assay and results of sequencing confirmed the PCR results. CONCLUSION: Notably, our highlighted findings are the first report of mazEF and RelBE TA loci in N. meningitides. Finally, we strongly recommended that laboratory experiments should be performed to identify the roles of these TA loci in N. meningitides.

Item Type: Article
Creators:
CreatorsEmail
Maleki, A.UNSPECIFIED
Ghafourian, S.UNSPECIFIED
Badakhsh, B.UNSPECIFIED
Pakzad, I.UNSPECIFIED
Sadeghifard, N.UNSPECIFIED
Keywords: Bacterial Proteins/metabolism Computational Biology DNA, Bacterial/analysis/genetics Humans Neisseria meningitidis/*genetics/*metabolism/pathogenicity Polymerase Chain Reaction Sequence Analysis, DNA Toxin-Antitoxin Systems/*genetics Transcription Factor RelB/genetics/metabolism Neisseria meningitides. abrB higAB mazEF relBe xre
Divisions:
Page Range: pp. 81-85
Journal or Publication Title: Infectious disorders drug targets
Journal Index: Pubmed
Volume: 17
Number: 2
Identification Number: https://doi.org/10.2174/1871526517666170427123533
ISSN: 2212-3989 (Electronic) 1871-5265 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1038

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