Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Synergistic Effect of Colistin and Rifampin Against Multidrug Resistant Acinetobacter baumannii: A Systematic Review and Meta-Analysis

Wed Sep 28 13:10:40 2022

(2017) Synergistic Effect of Colistin and Rifampin Against Multidrug Resistant Acinetobacter baumannii: A Systematic Review and Meta-Analysis. The open microbiology journal. pp. 63-71. ISSN 1874-2858 (Print) 1874-2858 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/28553417

Abstract

The existence of infections caused by multidrug resistant (MDR) Acinetobacter baumannii is a growing problem because of the difficulty to treat them. We examined the published literature and focused our analysis on the investigation of the synergism of colistin and rifampin against MDR A. baumannii isolates via systematic review and meta-analysis. A systematic literature search was performed using the following 4 databases (PubMed, Scopus, EMBASE and ISI Web of Sciences). The related articles were evaluated during the period from December 2014 to January 2015. Information based on resistance and sensitivity to antibiotics, the minimum inhibitory concentration and the effects of two antibiotics on each other including synergism, antagonism, relative synergism and additive antagonism were extracted. A meta-analysis of 17 studies including 448 samples was brought into process and 2 (95 CI 0-4) and 72 (95 CI 56-89) resistance to colistin and rifampin were observed, respectively. 42 of all isolates showed MIC = 4 microg/ml (95 CI 14-69) to rifampin and 30 MIC= 2 microg/ml to colistin (95 CI 3.8-78). MIC50 and MIC90 for both rifampin and colistin were 2 microg/ml and 4 microg/ml, respectively. 63 of the strains demonstrated synergy (95 CI 37-90), 7 were highlighted as relative synergism (95 CI 0.0- 13), 3 showed an additive effect (95 CI -0.0-7) and 14 were indifferent (95 CI 6-23). The antagonistic effect was not observed in this combination. Synergy rates of time-kill assay in rifampin and colistin combinations were generally higher than those of check bored microdilution and E-test method. The results demonstrated that the combination therapy could be more useful when compared to monotherapy and that this strategy might reduce the resistance rate to rifampin in MDR A. baumannii isolates.

Item Type: Article
Creators:
CreatorsEmail
Mohammadi, M.UNSPECIFIED
Khayat, H.UNSPECIFIED
Sayehmiri, K.UNSPECIFIED
Soroush, S.UNSPECIFIED
Sayehmiri, F.UNSPECIFIED
Delfani, S.UNSPECIFIED
Bogdanovic, L.UNSPECIFIED
Taherikalani, M.UNSPECIFIED
Keywords: A. baumannii Colistin Rifampin Synergism
Divisions:
Page Range: pp. 63-71
Journal or Publication Title: The open microbiology journal
Journal Index: Pubmed
Volume: 11
Identification Number: https://doi.org/10.2174/1874285801711010063
ISSN: 1874-2858 (Print) 1874-2858 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1033

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