Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Does Adding Intravenous Phosphorus to Parenteral Nutrition Has Any Effects on Calcium and Phosphorus Metabolism and Bone Mineral Content in Preterm Neonates?

Sun Oct 2 16:23:06 2022

(2017) Does Adding Intravenous Phosphorus to Parenteral Nutrition Has Any Effects on Calcium and Phosphorus Metabolism and Bone Mineral Content in Preterm Neonates? Acta medica Iranica. pp. 395-398. ISSN 1735-9694 (Electronic) 0044-6025 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/28843241

Abstract

The use of parenteral nutritional supplementation of phosphorus may lead to exhibit higher plasma phosphate concentrations and less radiological features in premature neonates susceptible to osteopenia. The present study aimed to assess the beneficial effects of adding intravenous phosphorus to total parenteral nutrition (TPN) on calcium and phosphorus metabolism in preterm neonates by measuring bone mineral content. This open-labeled randomized clinical trial was conducted on premature neonates who were hospitalized at NICU. The neonates were randomly assigned to two groups received TPN with intravenous sodium glycerophosphate or Glycophos (1.5 mmol/kg/day) or TPN without sodium glycerophosphate. At the end of the four weeks of treatment, the presence of osteopenia was examined using DEXA Scan. After completing treatment protocols, the group received TPN with intravenous Glycophos had significantly lower serum alkaline phosphatase (360+/-60 versus 762+/-71, P<0.001), as well as higher serum calcium to creatinine ratio (1.6+/-0.3 versus 0.44+/-0.13, P<0.001) compared to the control group received TPN without Glycophos. Those who received TPN with intravenous Glycophos experienced more increase in bone mineral density than those in control group (0.13+/-0.01 versus 0.10+/-0.02, P<0.001). There was no significant difference in serum calcium and serum vitamin D between the case and control groups. Adding intravenous sodium glycerophosphate to TPN in premature neonates can compensate the lack of bone mineral content and help to prevent osteopenia.

Item Type: Article
Creators:
CreatorsEmail
Mazouri, A.UNSPECIFIED
Khosravi, N.UNSPECIFIED
Bordbar, A.UNSPECIFIED
Khalesi, N.UNSPECIFIED
Saboute, M.UNSPECIFIED
Taherifard, P.UNSPECIFIED
Mirzababaee, M.UNSPECIFIED
Ebrahimi, M.UNSPECIFIED
Keywords: Absorptiometry, Photon *Bone Density Bone Diseases, Metabolic/*prevention & control Calcium/blood Female Glycerophosphates/administration & dosage Humans Infant, Newborn Male Parenteral Nutrition, Total/*methods Phosphorus/*administration & dosage/blood Vitamin D/blood Bone mineral density Calcium Premature infant Sodium glycerophosphate Total parenteral nutrition
Divisions:
Page Range: pp. 395-398
Journal or Publication Title: Acta medica Iranica
Journal Index: Pubmed
Volume: 55
Number: 6
ISSN: 1735-9694 (Electronic) 0044-6025 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1026

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