Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Protective effects of Smyrnium cordifolium boiss essential oil on pentylenetetrazol-induced seizures in mice: involvement of benzodiazepine and opioid antagonists

Thu Oct 6 07:33:48 2022

(2017) Protective effects of Smyrnium cordifolium boiss essential oil on pentylenetetrazol-induced seizures in mice: involvement of benzodiazepine and opioid antagonists. Journal of Biological Regulators and Homeostatic Agents. pp. 683-689. ISSN 0393-974X (Print) 0393-974X (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/28956418

Abstract

Smyrnium cordifolium as a wild plant is used in traditional medicine in Iran for the treatment of anxiety and insomnia. The anticonvulsant effect of this plant has not been studied to date, therefore this study aimed to evaluate the anticonvulsant effects of its essential oil and curzerene on seizure. Essential oil of the Smyrnium cordifolium plant was prepared by the hydro-distillation method. Gas chromatography and gas chromatography-mass spectroscopy analysis of the essential oil revealed its main components. Anticonvulsant effects of Smyrnium cordifolium essential oil (SCEO) and curzerene were examined on mice using the pentylentetrazole model (PTZ). Flumazenil (2 mg/kg, i.p) and naloxone (5 mg/kg, i.p) were injected into the relevant groups of mice to realize the anticonvulsant mechanism of SCEO and curzerene, respectively. The main identified components of the plant were curzerene (65.26), delta-Cadinene (14.39) and gamma-elemene (5.15), which comprised approximately 85.28 of SCEO. The ED50 values of SCEO and curzerene in the PTZ model were 223+/-15 and 0.25+/-0.09 mg/kg, respectively. Curzerene at the dosage of 0.4 mg/kg prolonged the onset time of seizure and decreased the duration of seizure among treated group compared to the saline group. At the dosage of 0.4 mg/kg, seizure and mortality protection rates for the treated group were 100. Flumazenil and naloxone could suppress the anticonvulsant effects of SCEO and curzerene. It seems that SCEO and curzerene are useful for the treatment of absence seizure and this effect may be related to their effects on GABAergic and opioid systems.

Item Type: Article
Creators:
CreatorsEmail
Abbasi, N.UNSPECIFIED
Mohammadpour, S.UNSPECIFIED
Karimi, E.UNSPECIFIED
Aidy, A.UNSPECIFIED
Karimi, P.UNSPECIFIED
Azizi, M.UNSPECIFIED
Asadollahi, K.UNSPECIFIED
Keywords: Animals Apiaceae/*chemistry Benzodiazepines/chemistry/*pharmacology Male Mice Mice, Inbred BALB C Narcotic Antagonists/chemistry/*pharmacology Oils, Volatile/chemistry/*pharmacology Pentylenetetrazole/*adverse effects/pharmacology *Seizures/chemically induced/drug therapy/physiopathology
Divisions:
Page Range: pp. 683-689
Journal or Publication Title: Journal of Biological Regulators and Homeostatic Agents
Journal Index: Pubmed
Volume: 31
Number: 3
ISSN: 0393-974X (Print) 0393-974X (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1022

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