Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Relationship between Plasma Concentrations of Maternal Zinc during Pregnancy and the Risk for Orofacial Cleft

Wed Sep 28 19:55:29 2022

(2018) Relationship between Plasma Concentrations of Maternal Zinc during Pregnancy and the Risk for Orofacial Cleft. Asian Journal of Pharmaceutics. S439-S443. ISSN 0973-8398

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Abstract

Aim: Recent studies have suggested the occurrence of a variety of abnormalities including oral clefts following the deficiency of nutritional elements. The present study aimed to address the association between plasma concentrations of maternal zinc and the risk of an infant being born with an orofacial cleft. Materials and Methods: In this case-control study conducted in Hamadan, Iran, 2015, 48 mothers of children with an isolated cleft lip with or without cleft palate and 48 control mothers of children with no congenital malformations were recruited. The concentration of zinc in the whole blood was measured using flame atomic absorption spectrometry method. Data were analyzed by the use of descriptive and analytical statistics in SPSS version 16. Results and Discussion: Plasma level of zinc in a group with orofacial clefts was 16.87 +/- 8.17 mu mol/L, and in the control group was 19.28 +/- 8.83 that was statistically similar between the groups (t = -1.329, P = 0.187). T-test showed that the two groups did not have a significant difference in zinc level. The odds ratio (OR) for the case and control group was 1.6, which indicates there was no significant difference in zinc deficiency between the two groups (OR = 1.66, 95 confidence interval = 0.61-4.54, P = 0.426). Conclusion: Despite lower zinc plasma levels in women of the case group, the difference in concentration of this element was not statistically significant between the two groups. In general, there is no definitive conclusion on whether the deficiency of nutritional elements during pregnancy is the cause of malformations or not, and it is still necessary to further studies.

Item Type: Article
Creators:
CreatorsEmail
Tiznobaik, A.UNSPECIFIED
Taheri, S.UNSPECIFIED
Momenimovahed, Z.UNSPECIFIED
Shirinzad, M.UNSPECIFIED
Dalband, M.UNSPECIFIED
Noorafrooz, A.UNSPECIFIED
Keywords: Case-control orofacial cleft plasma concentrations pregnancy zinc premature rupture clinical-trial deficiency diagnosis membranes supplementation copper genes women fluid Pharmacology & Pharmacy
Divisions:
Page Range: S439-S443
Journal or Publication Title: Asian Journal of Pharmaceutics
Journal Index: ISI
Volume: 12
Number: 2
ISSN: 0973-8398
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/102

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