Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Dissemination of Class 1, 2 and 3 Integrons among Different Multidrug Resistant Isolates of Acinetobacter baumannii in Tehran Hospitals, Iran

Mon May 23 16:12:46 2022

(2011) Dissemination of Class 1, 2 and 3 Integrons among Different Multidrug Resistant Isolates of Acinetobacter baumannii in Tehran Hospitals, Iran. Polish Journal of Microbiology. pp. 169-174. ISSN 1733-1331

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Abstract

A total of 100 non-duplicate Acinetobacter baumannii isolates were collected from different hospitals in Tehran and were confirmed as A. baumannii by conventional biochemical and API testing. Antimicrobial susceptibility of these isolates was checked by a disk diffusion method in accordance with CLSI guidelines. The isolates were then detected as carrying class 1 and 2 integron gene cassettes by PCR evaluation and then genotyped by REP-PCR. More than 50 (n = 50) of the isolates were multidrug resistant. The results showed that more than 80 of all multidrug resistant A. baumannii strains carry a class 1 integron. Distribution of IntI 1 and IntI2 among A. baumannii isolates was 58 and 14, respectively. Analysis of a conserved segment of class 1 integron showed a range from 100 bp to 2.5 kb. REP-PCR fingerprinting showed more than 20 genotypes among A. baumannii strains. There was no relationship between REP genotypes and the distribution of different classes of integrons. This is a comprehensive study on the distribution of different classes of integrons among A. baumannii in Iran. Considering the exact role of integrons in coding drug resistance in bacteria, the findings of this study could help us find antimicrobial resistant mechanisms among A. baumannii isolates in Iran.

Item Type: Article
Creators:
CreatorsEmail
Taherikalani, M.UNSPECIFIED
Maleki, A.UNSPECIFIED
Sadeghifard, N.UNSPECIFIED
Mohammadzadeh, D.UNSPECIFIED
Soroush, S.UNSPECIFIED
Asadollahi, P.UNSPECIFIED
Asadollahi, K.UNSPECIFIED
Emaneini, M.UNSPECIFIED
Keywords: A. baumannii hospital isolates in Iran integron classes intensive-care-unit molecular epidemiology antibiotic-resistance genes emergence diversity strains spp. Microbiology
Divisions:
Page Range: pp. 169-174
Journal or Publication Title: Polish Journal of Microbiology
Journal Index: ISI
Volume: 60
Number: 2
ISSN: 1733-1331
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/859

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