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Ilam University of Medical Sciences

TIME-KILL STUDY AND SYNERGISTIC ACTIVITY OF CELL-WALL INHIBITOR ANTIBIOTICS IN COMBINATION WITH GENTAMICIN AGAINST ENTEROCOCCUS FAECALIS AND ENTEROCOCCUS FAECIUM

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(2011) TIME-KILL STUDY AND SYNERGISTIC ACTIVITY OF CELL-WALL INHIBITOR ANTIBIOTICS IN COMBINATION WITH GENTAMICIN AGAINST ENTEROCOCCUS FAECALIS AND ENTEROCOCCUS FAECIUM. Acta Microbiologica Et Immunologica Hungarica. pp. 219-226. ISSN 1217-8950

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Abstract

The synergy between gentamicin and vancomycin, teicoplanin, ampicillin and linezolid was studied by time-kill method. Two clinical vancomycin resistant enterococci (VRE) and two vancomycin susceptible enterococci (VSE) isolates were used. Different concentrations of antibiotics were combined. Two VSE strains and the control strain exhibited synergism with the combination of gentamicin, vancomycin, teicoplanin, ampicillin and linezolid. Two VRE strains exhibited synergism with the combination of gentamicin and ampicillin. Synergy between gentamicin and vancomycin, teicoplanin and linezolid was not observed against these isolates. The VRE isolates were positive for vanA, aac (6')-Ie aph (2 '') and aph (3')-IIIa genes and their vancomycin, teicoplanin and gentamicin MICs were 512 mu g/ml, 512 mu g/ml and >4000 mu g/ml, respectively. In order to treat serious enterococcal infections, further clinical evaluation is needed to examine the in vitro combined effects of gentamicin and vancomycin, teicoplanin and linezolid.

Item Type: Article
Creators:
CreatorsEmail
Aligholi, M.UNSPECIFIED
Emaneini, M.UNSPECIFIED
Taherikalani, M.UNSPECIFIED
Shahsavan, S.UNSPECIFIED
Jabalameli, F.UNSPECIFIED
Asadollahi, P.UNSPECIFIED
Khoramian, B.UNSPECIFIED
Eslampour, M. A.UNSPECIFIED
Keywords: enterococci VRE VSE antimicrobial synergy time-kill vancomycin-resistant enterococci glycopeptides tehran iran pcr Immunology Microbiology
Divisions:
Page Range: pp. 219-226
Journal or Publication Title: Acta Microbiologica Et Immunologica Hungarica
Journal Index: ISI
Volume: 58
Number: 3
Identification Number: https://doi.org/10.1556/AMicr.58.2011.3.5
ISSN: 1217-8950
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/828

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