Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

In vitro study of the long-term cortisol treatment effects on the growth rate and proliferation of the neural stem/precursor cells

Wed May 25 21:08:23 2022

(2015) In vitro study of the long-term cortisol treatment effects on the growth rate and proliferation of the neural stem/precursor cells. Neurological Research. pp. 117-124. ISSN 0161-6412

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Abstract

Adult neural stem/precursor cells (NSPCs) residing in the subventricular zone of the lateral ventricles and the subgranular zone of the dentate gyrus of the hippocampus are involved in the memory formations and psychological problems. It is believed that basal levels of glucocorticoids are essential for neuronal development, plasticity, and survival, while stress-mediated levels of glucocorticoids produce neuronal loss. Degeneration of NSPCs by the apoptotic and necrotic stimuli have great devastating outcomes on the brain and contributes to the pathophysiology of neurological as well as psychological disorders. Using MTT assay, acridine orange, and TUNEL assay, we have demonstrated that cortisol at high and excessive (more than 5 mu M) levels had anti-proliferative effects on the NSPCs derived from subventricular and subgranular zones in a dose-and time-dependent manner through apoptosis as well as necrosis. These outcomes can highlight the role of stress-mediated decline of adult neurogenesis in the aging brain and interconnect stress-mediated cortisol secretion with brain aging diseases.

Item Type: Article
Creators:
CreatorsEmail
Abdanipour, A.UNSPECIFIED
Sagha, M.UNSPECIFIED
Noori-Zadeh, A.UNSPECIFIED
Pakzad, I.UNSPECIFIED
Tiraihi, T.UNSPECIFIED
Keywords: Cortisol NSPCs Adult neurogenesis Subventricular zone Dentate gyrus Neurosphere adult hippocampal neurogenesis pituitary-adrenal axis dentate gyrus alzheimers-disease glucocorticoid toxicity pattern separation striatal neurons critical period granule cells stress Neurosciences & Neurology
Divisions:
Page Range: pp. 117-124
Journal or Publication Title: Neurological Research
Journal Index: ISI
Volume: 37
Number: 2
Identification Number: https://doi.org/10.1179/1743132814y.0000000431
ISSN: 0161-6412
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/599

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