Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Prevalence of cagA and vacA among Helicobacter pylori-infected patients in Iran: a systematic review and meta-analysis

Wed May 25 20:46:39 2022

(2015) Prevalence of cagA and vacA among Helicobacter pylori-infected patients in Iran: a systematic review and meta-analysis. Journal of Infection in Developing Countries. pp. 686-696. ISSN 1972-2680

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Abstract

The varieties of infections caused by Helicobacter pylori may be due to differences in bacterial genotypes and virulence factors as well as environmental and host-related factors. This study aimed to investigate the prevalence of cagA and vacA genes among H. pylori-infected patients in Iran and analyze their relevance to the disease status between two clinical groups via a meta-analysis method. Different databases including PubMed, ISI, Scopus, SID, Magiran, Science Direct, and Medlib were investigated, and 23 relevant articles from the period between 2001 and 2012 were finally analyzed. The relevant data obtained from these papers were analyzed by a random-effects model. Data were analyzed using R software and STATA. The prevalence of cagA and vacA genes among H. pylori-infected patients was 70 (95 CI, 64-75) and 41 (95 CI, 24.3-57.7), respectively. The prevalence of duodenal ulcers, peptic ulcers, and gastritis among cagA+ individuals was 53 (95 CI, 20-86), 65 (95 CI, 34-97), and 71 (95 CI, 59-84), respectively. Odds ratio (OR) between cagA-positive compared with cagA-negative patients showed a 1.89 (95 CI, 1.38-2.57) risk of ulcers. In conclusion, the frequency of cagA gene among H. pylori strains is elevated in Iran and it seems to be more frequently associated with gastritis. Therefore, any information about cagA and vacA prevalence among different H. pylori-infected clinical groups in the country can help public health authorities to plan preventive policies to reduce the prevalence of diseases associated with H. pylori infection.

Item Type: Article
Creators:
CreatorsEmail
Sayehmiri, F.UNSPECIFIED
Kiani, F.UNSPECIFIED
Sayehmiri, K.UNSPECIFIED
Soroush, S.UNSPECIFIED
Asadollahi, K.UNSPECIFIED
Alikhani, M. Y.UNSPECIFIED
Delpisheh, A.UNSPECIFIED
Emaneini, M.UNSPECIFIED
Bogdanovic, L.UNSPECIFIED
Varzi, A. M.UNSPECIFIED
Zarrilli, R.UNSPECIFIED
Taherikalani, M.UNSPECIFIED
Keywords: cagA vacA prevalence H. pylori meta-analysis Iran peptic-ulcer disease different ethnic-groups gastroduodenal diseases gastric-cancer nonulcer dyspepsia gastrointestinal-diseases vacuolating cytotoxin pathogenicity island gene polymorphisms clinical-outcomes Infectious Diseases
Divisions:
Page Range: pp. 686-696
Journal or Publication Title: Journal of Infection in Developing Countries
Journal Index: ISI
Volume: 9
Number: 7
Identification Number: https://doi.org/10.3855/jidc.5970
ISSN: 1972-2680
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/564

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