Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Anti-tuberculosis drugs sensitivity of BCG pasture strain isolated from lymphadenitis of children after vaccination by BCG vaccine

Fri May 20 01:54:52 2022

(2017) Anti-tuberculosis drugs sensitivity of BCG pasture strain isolated from lymphadenitis of children after vaccination by BCG vaccine. International Journal of Advanced Biotechnology and Research. pp. 828-834. ISSN 0976-2612

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Abstract

The common disadvantages of BCG vaccine is topical lymphadenitis, this patient must be treatment by anti-tuberculosis drugs. Systematic form of lymphadenitis has high mortality. This study aimed to evaluate anti tuberculosis drugs sensitivity of BCG pasture strain isolated from children with lymphadenitis after BCG vaccination to compare with BCG pasture strain. The samples from children with lymphadenitis were collected and cultured on glycerol free-middle brook 7h11 and lowenstien Jensen. The positive culture was confirmed by real time PCR and MIC of Ethionamide, Rifampicin and. For BCG pasture strain vaccination and isolation from adults was determined. In the all samples the 30 cases (37.5) had positive culture, in 2 cases of which, because of patient`s underlying immunodeficiency, the co-bacterial infection was observed. The MIC of Isoniazid, Rifampicin, Streptomycin, Ethambutol, Clarithromycin, Amikacin and Ethionamide in pasture strain of BCG vaccine and adenitis almost were similar. In order to similarity of anti-tuberculosis drugs, sensitivity of vaccine strain and adenitis in systemic cases, the first line drug could use.

Item Type: Article
Creators:
CreatorsEmail
Mohamadi, J.UNSPECIFIED
Panahi, J.UNSPECIFIED
Alborzi, A.UNSPECIFIED
Pakzad, I.UNSPECIFIED
Pourabas, B.UNSPECIFIED
Rezai, Z.UNSPECIFIED
Havasian, M. R.UNSPECIFIED
Keywords: Mycobacterium Bovis-BCG lymphadenitis anti-tuberculosis drugs mycobacterium-bovis bcg bacillus-calmette-guerin tuberculosis metaanalysis osteomyelitis substrains prevention carcinoma efficacy bladder Biotechnology & Applied Microbiology
Divisions:
Page Range: pp. 828-834
Journal or Publication Title: International Journal of Advanced Biotechnology and Research
Journal Index: ISI
Volume: 8
Number: 2
ISSN: 0976-2612
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/382

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