Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Colonic mucosal infiltration of igg4 plasma cells and ulcerative colitis: Determinant of presence, activity, extension, and duration of disease

Sun May 29 01:15:59 2022

(2021) Colonic mucosal infiltration of igg4 plasma cells and ulcerative colitis: Determinant of presence, activity, extension, and duration of disease. Middle East Journal of Digestive Diseases. pp. 287-293. ISSN 20085230 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

BACKGROUND Infiltration of IgG4 positive plasma cells has been detected in the colonic mucosa of patients with ulcerative colitis (UC). The aim of the study was to investigate the association between colonic mucosal infiltration of IgG4 plasma cells and the presence, activity, extension, and duration of UC. METHODS In this case-control study (2009-2014), 102 subjects (84 with UC/18 controls) were enrolled. Clinical records and rectosigmoid biopsies of UC patients were selected, and biopsies were stained with IgG4 monoclonal antibodies. IgG4 positive plasma cells were counted by a single pathologist. RESULTS Amongst 84 patients with UC, 73.8 had UC without primary sclerosing cholangitis (PSC), and 26.2 had UC with PSC. IgG4 plasma cells were seen in 35 (41.7) patients with UC and 0 of controls (p = 0.001). The mean amount of IgG4 containing plasma cells was significantly different between active and inactive patients with UC, although it was not significantly different between UC patients with and without PSC. The presence of IgG4 infiltration was significantly associated with the extension and duration of the disease. Furthermore, IgG4 count had a sensitivity/specificity of 78.6/83.3 for the diagnosis of UC. CONCLUSION Our study revealed the diagnostic role of IgG4 plasma cells in the colonic mucosa of patients with UC and its association with activity, extension, and duration of disease. © 2021 The Author(s).

Item Type: Article
Creators:
CreatorsEmail
Alborzi, F.UNSPECIFIED
Daryani, N. E.UNSPECIFIED
Deihim, T.UNSPECIFIED
Azizi, Z.UNSPECIFIED
Ardalan, F. A.UNSPECIFIED
Teimouri, A.UNSPECIFIED
Taslimi, R.UNSPECIFIED
Roshan, N.UNSPECIFIED
Mami, M.UNSPECIFIED
Mirzade, M.UNSPECIFIED
Aletaha, N.UNSPECIFIED
Keywords: Disease activity Duration of disease Extension of disease IgG4 plasma cells Primary sclerosing cholangitis Ulcerative colitis
Divisions:
Page Range: pp. 287-293
Journal or Publication Title: Middle East Journal of Digestive Diseases
Journal Index: Scopus
Volume: 13
Number: 4
Identification Number: https://doi.org/10.34172/mejdd.2021.237
ISSN: 20085230 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3780

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