Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Treatment Failure in Cutaneous Leishmaniasis Patients Referred to the School of Public Health, Tehran University of Medical Sciences During 2008-2017

Sat May 28 12:55:37 2022

(2020) Treatment Failure in Cutaneous Leishmaniasis Patients Referred to the School of Public Health, Tehran University of Medical Sciences During 2008-2017. Journal of Arthropod-Borne Diseases. pp. 363-375. ISSN 2322-1984

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Abstract

Background: Cutaneous leishmaniasis (CL) is a vector borne disease predominantly found in tropical and subtropical countries, including Iran. For more than 6 decades, pentavalent antimonials have been used successfully worldwide for the treatment of leishmaniasis, but over the past few years, clinical resistance to these medications has increased. In this study, we evaluated CL patients who did not show any desirable responses to the anti-leishmanial treatment within a 10-year period (2008 to 2017). Methods: All patients from different parts of Iran suspected of having cutaneous leishmaniasis, who were referred to the laboratory of leishmaniosis in Tehran University of Medical Sciences from 2008-2017 were parasitological examined. Results: During this period, a total of 1480 suspected CL patients were referred to the laboratory of leishmaniosis. Samples from 655 patients (70.8) suspected of having CL were positive microscopically. The failure rate in patients treated with anti-leishmaniasis medications for a minimum of three complete treatment periods was 1.83 (12 cases). There was no association between the number and size of skin lesions and patient characteristics. Also, the route of drug administration had no significant effect on the number and size of lesions. Conclusion: In the present study, treatment failure was found in some confirmed CL patients treated with meglumine antimoniate. Over the past few years, it seems that had been increased in resistance to these medications. So, a review of the correct implementation of the treatment protocol and/or a combination therapy may be helpful in preventing an increase in the rate of treatment failure.

Item Type: Article
Creators:
CreatorsEmail
Kakooei, Z.UNSPECIFIED
Hajjaran, H.UNSPECIFIED
Akhoundi, B.UNSPECIFIED
Charehdar, S.UNSPECIFIED
Elikaee, S.UNSPECIFIED
Shafeghat, Z.UNSPECIFIED
Hassanpour, H.UNSPECIFIED
Satvat, M. T.UNSPECIFIED
Kazemi-Rad, E.UNSPECIFIED
Mohebali, M.UNSPECIFIED
Keywords: Cutaneous leishmaniasis Anti-Leishmania drug Treatment failure Iran flies diptera psychodidae insecticide susceptibility status visceral leishmaniasis phlebotomus-papatasi sand flies endemic focus antimony resistance drug-resistance zinc phosphide meglumine antimoniate Public, Environmental & Occupational Health Parasitology
Divisions:
Page Range: pp. 363-375
Journal or Publication Title: Journal of Arthropod-Borne Diseases
Journal Index: ISI
Volume: 14
Number: 4
ISSN: 2322-1984
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3345

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